Mouse anti-Human CD62L Antibody | anti-CD62L antibody

CD62L

Cat. Num. AAA396572

• Gene Names: SELL; TQ1; LAM1; LEU8; LNHR; LSEL; CD62L; LYAM1; PLNHR; LECAM1
• Reactivity: Human
• Applications: Flow Cytometry, Functional Assay
• Purity: Protein A/G Chromatography
• Synonyms: CD62L; anti-CD62L antibody

• Host: Mouse
• Reactivity: Human
• Isotype: IgG2a
• Clone Number: 1H3
• Purity/Purification: Protein A/G Chromatography
• Form/Format: Provided as solution in phosphate buffered saline with 0.08% sodium azide
• Sequence Length: 385

• Applicable Applications for anti-CD62L antibody: Flow Cytometry (FC/FACS)
• Immunogen: CD62L=Derived from the hybridization of mouse NS-1 myeloma cells with spleen cells from BALB/c mice immunized with perherial blood T lymphocytes.
• Preparation and Storage: Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles

Related Product Information for anti-CD62L antibody

CD62L is the equivalent of the mouse MEL-14 with a molecular weight of 80 kDa. CD62L is on 60-75% of peripheral blood lymphocytes, Approximately 70-80% of T cells, 10% of thymocytes and most B cells. CD62L reacts with monocytes, granulocytes and a subset of NK cells. The selectins represent a family of adhesion molecules, expressed by leukocytes and endothelial cells that are involved in the regulation of leukocyte traffic. Human leukocyte L selectin is also called LAM-1, LECAM-1, or gp90MEL-14. This antibody to L selectin blocks greater than 95% of lymphocyte adhesion to peripheral lymph node high endothelial venules.

Product Categories/Family for anti-CD62L antibody

Single-Color Reagent; Single Color Markers

NCBI and Uniprot Product Information

• NCBI GI #: 262206315
• NCBI GeneID: 6402
• NCBI Accession #: NP_000646.2
• NCBI GenBank Nucleotide #: NM_000655.4
• UniProt Accession #: P14151; P15023; Q9UJ43; B2R6Q8
• Molecular Weight: 42,187 Da
• NCBI Official Full Name: L-selectin
• NCBI Official Synonym Full Names: selectin L
• NCBI Official Symbol: SELL
• NCBI Official Synonym Symbols: TQ1; LAM1; LEU8; LNHR; LSEL; CD62L; LYAM1; PLNHR; LECAM1
• NCBI Protein Information: L-selectin; gp90-MEL; pln homing receptor; lymph node homing receptor; lymphocyte adhesion molecule 1; leukocyte surface antigen Leu-8; CD62 antigen-like family member L; leukocyte-endothelial cell adhesion molecule 1
• UniProt Protein Name: L-selectin
• UniProt Gene Name: SELL
• UniProt Synonym Gene Names: LNHR; LYAM1; LAM-1; LECAM1
• UniProt Entry Name: LYAM1_HUMAN

NCBI Description

This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]

Uniprot Description

Function: Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. Ref.12

Subunit structure: Interaction with PSGL1/SELPLG and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of PSGL1 and PODXL2, and tyrosine sulfation modifications of PSGL1. Sulfation on 'Tyr-51' of PSGL1 is important for L-selectin binding.

Subcellular location: Membrane; Single-pass type I membrane protein.

Tissue specificity: Expressed in B-cell lines and T-lymphocytes. Ref.2

Sequence similarities: Belongs to the selectin/LECAM family.Contains 1 C-type lectin domain.Contains 1 EGF-like domain.Contains 2 Sushi (CCP/SCR) domains.

Sequence caution: The sequence CAA34203.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence CAB43536.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence CAB43537.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.