Western Blot/Blotting
(Western blot analysis)
Rabbit Kv1.1Potassium Channel Polyclonal Antibody | anti-Kcna1 antibody
Kv1.1Potassium Channel
Western Blot/Blotting
(Western blot analysis)
Western Blot/Blotting
(Western blot analysis)
NCBI and Uniprot Product Information
NCBI Description
voltage-gated potassium channel; activation is delayed [RGD, Feb 2006]
Uniprot Description
Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
Subunit structure: Heterotetramer of potassium channel proteins. Binds KCNAB2
By similarity. Binds PDZ domains of DLG1, DLG2 and DLG4. Interacts with LGI1 within a complex containing LGI1, KCNA4 and KCNAB1. Ref.4 Ref.5 Ref.6
Subcellular location: Membrane; Multi-pass membrane protein.
Domain: The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Post-translational modification: Palmitoylated on Cys-243; which may be required for membrane targeting
By similarity.
Sequence similarities: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.1/KCNA1 sub-subfamily. [View classification]
RNA editing: Edited at position 400.Partially edited. RNA editing is at an average of 50% in the whole brain. Ref.3
Research Articles on Kcna1
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Product Notes
The Kcna1 kcna1 (Catalog #AAA396013) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Kv1.1Potassium Channel reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Kv1.1Potassium Channel can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the Kcna1 kcna1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Kv1.1Potassium Channel, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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