Immunohistochemistry (IHC)
(Human kidney section stained with anti-SMS-1 antibody (Cat X2065P) at 2 ug/ml. Anti-rabbit Ig H+L HRP conjugate (5 ug/ml) without antigen retrieval.)
Rabbit anti-Human, Mouse Sphingomyelin Synthase 1 Polyclonal Antibody | anti-SGMS1 antibody
Sphingomyelin Synthase 1
Immunohistochemistry (IHC)
(Human kidney section stained with anti-SMS-1 antibody (Cat X2065P) at 2 ug/ml. Anti-rabbit Ig H+L HRP conjugate (5 ug/ml) without antigen retrieval.)
Immunohistochemistry (IHC)
(Human kidney section stained with anti-SMS-1 antibody (Cat X2065P) at 2 ug/ml. Anti-rabbit Ig H+L HRP conjugate (5 ug/ml) without antigen retrieval.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is predicted to be a five-pass transmembrane protein. This gene may be predominately expressed in brain. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types such as HeLa cells. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide. Ref.10 Ref.12
Catalytic activity: A ceramide + a phosphatidylcholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol.
Enzyme regulation: Inhibited by bacterial PC-phospholipase C inhibitor D609. Ref.10
Subcellular location: Golgi apparatus membrane; Multi-pass membrane protein Ref.10 Ref.12 Ref.13.
Tissue specificity: Brain, heart, kidney, liver, muscle and stomach. Ref.7 Ref.9 Ref.10
Miscellaneous: Overexpression of the human protein in mouse causes increased non-HDL-sphingomyelin and non-HDL cholesterol levels, decreased HDL-sphingomyelin and HDL-cholesterol levels and increases lipoprotein atherogenic potential.
Sequence similarities: Belongs to the sphingomyelin synthase family.Contains 1 SAM (sterile alpha motif) domain.
Sequence caution: The sequence AAH42899.1 differs from that shown. Reason: Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.The sequence AAP37279.1 differs from that shown. Reason: Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.The sequence AAQ22363.1 differs from that shown. Reason: Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.The sequence AAQ82051.1 differs from that shown. Reason: Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.The sequence AK026683 differs from that shown. Reason: Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.The sequence BAD16809.1 differs from that shown. Reason: Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.The sequence CAD79708.1 differs from that shown. Reason: Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.
Research Articles on SGMS1
Similar Products
Product Notes
The SGMS1 sgms1 (Catalog #AAA395672) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Sphingomyelin Synthase 1 reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Sphingomyelin Synthase 1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the SGMS1 sgms1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Sphingomyelin Synthase 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
