Mouse anti-Human RAP1/TERF2IP Monoclonal Antibody | anti-RAP1/TERF2IP antibody
RAP1/TERF2IP antibody (mAb)(Clone 4C8)
Gene Names
TERF2IP; RAP1; DRIP5
Reactivity
Human
Applications
Western Blot
Purity
Protein G Chromatography
Synonyms
RAP1/TERF2IP; Monoclonal Antibody; RAP1/TERF2IP antibody (mAb)(Clone 4C8); DRIP5; anti-RAP1/TERF2IP antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
4C8
Purity/Purification
Protein G Chromatography
Form/Format
Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic.
Concentration
1ug/ul (varies by lot)
Applicable Applications for anti-RAP1/TERF2IP antibody
Western Blot (WB)
Immunogen
This RAP1/TERF2IP antibody was raised against a protein corresponding to full-length human RAP1/TERF2IP.
Preparation and Storage
Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20 degree C for up to 2 years. Keep all reagents on ice when not in storage.1ug/ul
Related Product Information for anti-RAP1/TERF2IP antibody
Short Description: Our RAP1/TERF2IP antibody (mAb)(Clone 4C8) was raised in a Mouse host. It has been validated for use in Western blot; it has been shown to react with Human samples.
Background: RAP1/TERF2IP (Repressor/activator protein 1, Telomeric repeat-binding factor 2-interacting protein 1) is a protein associated with telomeres that acts both as a modulator of telomere function and as a regulator of transcription. RAP1 is a component of the shelterin (telosome) protein complex and is involved in the regulation of telomere length and serves to protect telomeric repeats from degradation. In contrast to other components of the shelterin complex, RAP1 is dispensable for telomere end-capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. RAP1 is recruited to telomeric repeats via its interaction with TERF2. Independent of its function in telomeres, RAP1 also acts as a transcriptional regulator. It is recruited to non-telomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. RAP1 is also present in the cytoplasm and associates with the IkB-kinase (IKK) complex and acts as a regulator of the NFkB signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activation of the expression of NFkB target genes.
Background: RAP1/TERF2IP (Repressor/activator protein 1, Telomeric repeat-binding factor 2-interacting protein 1) is a protein associated with telomeres that acts both as a modulator of telomere function and as a regulator of transcription. RAP1 is a component of the shelterin (telosome) protein complex and is involved in the regulation of telomere length and serves to protect telomeric repeats from degradation. In contrast to other components of the shelterin complex, RAP1 is dispensable for telomere end-capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. RAP1 is recruited to telomeric repeats via its interaction with TERF2. Independent of its function in telomeres, RAP1 also acts as a transcriptional regulator. It is recruited to non-telomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. RAP1 is also present in the cytoplasm and associates with the IkB-kinase (IKK) complex and acts as a regulator of the NFkB signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activation of the expression of NFkB target genes.
Product Categories/Family for anti-RAP1/TERF2IP antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
44,260 Da
NCBI Official Full Name
telomeric repeat-binding factor 2-interacting protein 1
NCBI Official Synonym Full Names
telomeric repeat binding factor 2, interacting protein
NCBI Official Symbol
TERF2IP
NCBI Official Synonym Symbols
RAP1; DRIP5
NCBI Protein Information
telomeric repeat-binding factor 2-interacting protein 1; RAP1 homolog; TERF2-interacting telomeric protein 1; TRF2-interacting telomeric RAP1 protein; TRF2-interacting telomeric protein 1; dopamine receptor interacting protein 5; dopamine receptor-interac
UniProt Protein Name
Telomeric repeat-binding factor 2-interacting protein 1
UniProt Gene Name
TERF2IP
UniProt Synonym Gene Names
DRIP5; RAP1; TERF2-interacting telomeric protein 1; TRF2-interacting telomeric protein 1; RAP1 homolog; hRap1
UniProt Entry Name
TE2IP_HUMAN
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Product Notes
The RAP1/TERF2IP terf2ip (Catalog #AAA388821) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The RAP1/TERF2IP antibody (mAb)(Clone 4C8) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's RAP1/TERF2IP can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the RAP1/TERF2IP terf2ip for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RAP1/TERF2IP, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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