Rat CXC-Chemokine Receptor 3 (CXCR3) ELISA Kit | CXCR3 elisa kit

Rat CXC-Chemokine Receptor 3 (CXCR3) ELISA Kit

Cat. Num. AAA3807609

• Gene Names: CXCR3; GPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R
• Reactivity: Rat
• Synonyms: CXC-Chemokine Receptor 3 (CXCR3); Rat CXC-Chemokine Receptor 3 (CXCR3) ELISA Kit; CXCR3 elisa kit

• Reactivity: Rat
• Sequence Length: 368

• Samples: Serum, plasma, cell culture supernate and other biological fluids
• Assay Type: Sandwich
• Detection Range: 0.5ng/ml-8ng/ml
• Sensitivity: 0.1 ng/ml

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for CXCR3 elisa kit

Intended Use: The Stop Solution changes the color from blue to yellow and the intensity of the color is measured at 450 nm using a spectrophotometer. In order to measure the concentration ofCXCR3in the sample, This CXCR3ELISA Kit includes a set of calibration standards. The calibration standards are assayed at the same time as the samples and allow the operator to produce a standard curve of Optical Density versusCXCR3concentration. The concentration ofCXCR3in the samples is then determined by comparing the O.D. of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 4504099
• NCBI GeneID: 2833
• NCBI GenBank Nucleotide #: NP_001495.1
• UniProt Accession #: P49682
• NCBI Official Full Name: C-X-C chemokine receptor type 3 isoform 1
• NCBI Official Synonym Full Names: C-X-C motif chemokine receptor 3
• NCBI Official Symbol: CXCR3
• NCBI Official Synonym Symbols: GPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R
• NCBI Protein Information: C-X-C chemokine receptor type 3
• UniProt Protein Name: C-X-C chemokine receptor type 3
• Protein Family: C-X-C chemokine receptor
• UniProt Gene Name: CXCR3
• UniProt Synonym Gene Names: GPR9; CXC-R3; CXCR-3
• UniProt Entry Name: CXCR3_HUMAN

NCBI Description

This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]

Uniprot Description

CXCR3: Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC). Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1

Chromosomal Location of Human Ortholog: Xq13

Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; external side of plasma membrane

Molecular Function: C-X-C chemokine binding; chemokine binding; chemokine receptor activity; receptor activity; C-X-C chemokine receptor activity

Biological Process: apoptosis; positive regulation of chemotaxis; calcium-mediated signaling; positive regulation of cAMP metabolic process; chemotaxis; G-protein coupled receptor protein signaling pathway; positive regulation of angiogenesis; elevation of cytosolic calcium ion concentration; negative regulation of angiogenesis; cell surface receptor linked signal transduction; regulation of leukocyte migration; negative regulation of endothelial cell proliferation; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of release of sequestered calcium ion into cytosol; angiogenesis; cell motility; inflammatory response; cell adhesion