Mouse Peroxisome Proliferators Activator Receptors Delta ELISA Kit | PPARD elisa kit

Mouse Peroxisome Proliferators Activator Receptors Delta ELISA Kit

Cat. Num. AAA3807292

• Gene Names: PPARD; FAAR; NUC1; NUCI; NR1C2; NUCII; PPARB
• Reactivity: Mouse
• Synonyms: Peroxisome Proliferators Activator Receptors Delta; Mouse Peroxisome Proliferators Activator Receptors Delta ELISA Kit; PPARD elisa kit

• Reactivity: Mouse
• Sequence Length: 441

• Samples: Serum, plasma, cell culture supernate and other biological fluids
• Assay Type: Sandwich
• Detection Range: 0.5ng/ml-8ng/ml
• Sensitivity: 0.1 ng/ml

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for PPARD elisa kit

Intended Use: The Stop Solution changes the color from blue to yellow and the intensity of the color is measured at 450 nm using a spectrophotometer. In order to measure the concentration ofPEROXISOME PROLIFERATORS ACTIVATOR RECEPTORS deltain the sample, This PEROXISOME PROLIFERATORS ACTIVATOR RECEPTORS deltaELISA Kit includes a set of calibration standards. The calibration standards are assayed at the same time as the samples and allow the operator to produce a standard curve of Optical Density versusPEROXISOME PROLIFERATORS ACTIVATOR RECEPTORS deltaconcentration. The concentration ofPEROXISOME PROLIFERATORS ACTIVATOR RECEPTORS deltain the samples is then determined by comparing the O.D. of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 417522
• NCBI GeneID: 5467
• UniProt Accession #: Q03181
• NCBI Official Full Name: Peroxisome proliferator-activated receptor delta
• NCBI Official Synonym Full Names: peroxisome proliferator activated receptor delta
• NCBI Official Symbol: PPARD
• NCBI Official Synonym Symbols: FAAR; NUC1; NUCI; NR1C2; NUCII; PPARB
• NCBI Protein Information: peroxisome proliferator-activated receptor delta
• UniProt Protein Name: Peroxisome proliferator-activated receptor delta
• Protein Family: Peroxisome proliferator-activated receptor
• UniProt Gene Name: PPARD
• UniProt Synonym Gene Names: NR1C2; PPARB; PPAR-delta; NUC1; PPAR-beta
• UniProt Entry Name: PPARD_HUMAN

NCBI Description

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. The encoded protein is thought to function as an integrator of transcriptional repression and nuclear receptor signaling. It may inhibit the ligand-induced transcriptional activity of peroxisome proliferator activated receptors alpha and gamma, though evidence for this effect is inconsistent. Expression of this gene in colorectal cancer cells may be variable but is typically relatively low. Knockout studies in mice suggested a role for this protein in myelination of the corpus callosum, lipid metabolism, differentiation, and epidermal cell proliferation. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Aug 2017]

Uniprot Description

PPAR-delta: Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand. Belongs to the nuclear hormone receptor family. NR1 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Nuclear receptor

Chromosomal Location of Human Ortholog: 6p21.2

Cellular Component: nucleoplasm; nucleus

Molecular Function: NF-kappaB binding; ligand-dependent nuclear receptor activity; protein binding; DNA binding; zinc ion binding; sequence-specific DNA binding; transcription coactivator activity; steroid hormone receptor activity; drug binding; transcription factor activity; lipid binding

Biological Process: proteoglycan metabolic process; wound healing; negative regulation of smooth muscle cell proliferation; negative regulation of collagen biosynthetic process; heart development; positive regulation of transcription, DNA-dependent; positive regulation of epidermis development; negative regulation of smooth muscle cell migration; glucose transport; negative regulation of transcription from RNA polymerase II promoter; decidualization; positive regulation of vasodilation; vitamin A metabolic process; response to vitamin A; positive regulation of cell proliferation; response to glucose stimulus; axon ensheathment; cell differentiation; negative regulation of epithelial cell proliferation; transcription initiation from RNA polymerase II promoter; cholesterol metabolic process; generation of precursor metabolites and energy; intracellular receptor-mediated signaling pathway; glucose metabolic process; positive regulation of insulin secretion; fatty acid catabolic process; keratinocyte proliferation; keratinocyte migration; cell-substrate adhesion; phospholipid biosynthetic process; regulation of transcription from RNA polymerase II promoter; positive regulation of phosphoinositide 3-kinase cascade; cell proliferation; fatty acid beta-oxidation; negative regulation of inflammatory response; mRNA transcription; positive regulation of fat cell differentiation; steroid hormone mediated signaling; gene expression; lipid metabolic process; negative regulation of cell growth; response to activity; negative regulation of transcription, DNA-dependent; fatty acid transport; embryo implantation; negative regulation of apoptosis