Human Nuclear Factor Of Activated T-Cells 1 ELISA Kit | NFATC3 elisa kit

Human Nuclear Factor Of Activated T-Cells 1 ELISA Kit

Cat. Num. AAA3803720

• Gene Names: NFATC3; NFAT4; NFATX; NF-AT4c
• Reactivity: Human
• Synonyms: Nuclear Factor Of Activated T-Cells 1; Human Nuclear Factor Of Activated T-Cells 1 ELISA Kit; NFATC3 elisa kit

• Reactivity: Human
• Sequence Length: 1075

• Samples: Serum, plasma, cell culture supernate and other biological fluids
• Assay Type: Sandwich
• Detection Range: 125 pg/ml-2000 pg/ml
• Sensitivity: 10 pg/ml

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for NFATC3 elisa kit

Intended Use: The Stop Solution changes the color from blue to yellow and the intensity of the color is measured at 450 nm using a spectrophotometer. In order to measure the concentration ofNUCLEAR FACTOR OF ACTIVATED T-CELLS 1in the sample, This NUCLEAR FACTOR OF ACTIVATED T-CELLS 1ELISA Kit includes a set of calibration standards. The calibration standards are assayed at the same time as the samples and allow the operator to produce a standard curve of Optical Density versusNUCLEAR FACTOR OF ACTIVATED T-CELLS 1concentration. The concentration ofNUCLEAR FACTOR OF ACTIVATED T-CELLS 1in the samples is then determined by comparing the O.D. of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 27886561
• NCBI GeneID: 4775
• NCBI GenBank Nucleotide #: NP_775188.1
• UniProt Accession #: Q12968
• NCBI Official Full Name: nuclear factor of activated T-cells, cytoplasmic 3 isoform 1
• NCBI Official Synonym Full Names: nuclear factor of activated T cells 3
• NCBI Official Symbol: NFATC3
• NCBI Official Synonym Symbols: NFAT4; NFATX; NF-AT4c
• NCBI Protein Information: nuclear factor of activated T-cells, cytoplasmic 3
• UniProt Protein Name: Nuclear factor of activated T-cells, cytoplasmic 3
• Protein Family: Nuclear factor of activated T-cells
• UniProt Gene Name: NFATC3
• UniProt Synonym Gene Names: NFAT4; NF-ATc3; NFATc3; NF-AT4
• UniProt Entry Name: NFAC3_HUMAN

NCBI Description

The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2010]

Uniprot Description

NFAT4: a transcription factor that plays a role in the inducible expression of cytokine genes in T cells. Plays a role in the regulation of gene expression in T cells and immature thymocytes. Six spliced isoforms have been identified. Isoform 1 is predominantly expressed in thymus, peripheral blood leukocytes and kidney. Isoform 2 is predominantly expressed in skeletal muscle and is also found in thymus, kidney, testis, spleen, prostate, ovary, small intestine, heart, placenta and pancreas. Isoform 3 is expressed in thymus and kidney. Isoform 4 is expressed in thymus and skeletal muscle.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 16q22.2

Cellular Component: nucleoplasm; cytoplasm; nucleolus; cytosol; nucleus

Molecular Function: protein binding; chromatin binding

Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; patterning of blood vessels; heart development; cellular respiration; muscle cell development; innate immune response; smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; inflammatory response