Structure
Capmatinib 2HCl, Inhibitor
Capmatinib 2HCl
Purity
>98% (HPLC)
Synonyms
Capmatinib 2HCl; inhibitor
Purity/Purification
>98% (HPLC)
Target
Proton pump
Receptor
c-Met
SMILES
Cl.Cl.CNC(=O)c1ccc(cc1F)c4cnc5ncc(Cc2cc3cccnc3cc2)n5n4
Molecular Formula
C23H19Cl2FN6O
CAS Number
1197376-85-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Capmatinib 2HCl, inhibitor
INCB-28060 (free base) is a novel, ATP-competitive inhibitor of c-MET kinase with an IC50 with 0.13nM. INCB28060 exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10,000-fold selectivity over a large panel of human kinases. This inhibitor potently blocks c-MET phosphorylation and activation of its key downstream effectors in c-MET-dependent tumor cell lines. As a result, INCB 28060 potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis in vitro.
Product Categories/Family for Capmatinib 2HCl, inhibitor
References
1.Liu X, et al, A novel kinase inhibitor, INCB28060, blocks c-MET-dependent signaling, neoplastic activities, and cross-talk with EGFR and HER-3. Clin Cancer Res, 2011, 17 (227). 7127-7138.
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Product Notes
The Capmatinib 2HCl (Catalog #AAA3607865) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Capmatinib 2HCl, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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