Structure
Clemizole, Inhibitor
Clemizole
Purity
>98% (HPLC)
Synonyms
Clemizole; NSC 46261; NSC-46261; NSC46261; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
TRP/TRPV Channel
Receptor
NS4BH1histaminereceptor
Chemical Name
1H-Benzimidazole, 1-[(4-chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)
SMILES
ClC1=CC=C(C=C1)CN2C3=CC=CC=C3N=C2CN4CCCC4
Molecular Formula
C19H20ClN3
CAS Number
442-52-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Clemizole, inhibitor
An H1 histamine receptor antagonist that substantially inhibits HCV replication by suppression of NS4B's RNA binding (IC50=24nM) with little toxicity for the host cells; also selectively and efficiently blocks TRPC5 currents and Ca (2+) entry with IC50 of 1-1.3uM, 6-fold selectivity over TRPC4beta (IC50=6.4uM), and almost 10-fold selectivity over TRPC3 (IC50 =9.1uM) and TRPC6 (IC50=11.3uM), only very weakly affects TRPM3, TRPM8 and TRPV1, V2, V3, and V4 channels. HCV Infection Phase 2 Clinical
Product Categories/Family for Clemizole, inhibitor
References
1. Richter JM, et al. Mol Pharmacol. 2014 Nov; 86 (5):514-21.
2. Einav S, et al. Nat Biotechnol. 2008 Sep; 26 (9):1019-27.
3. Einav S, et al. J Infect Dis. 2010 Jul 1; 202 (1):65-74.
2. Einav S, et al. Nat Biotechnol. 2008 Sep; 26 (9):1019-27.
3. Einav S, et al. J Infect Dis. 2010 Jul 1; 202 (1):65-74.
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Product Notes
The Clemizole (Catalog #AAA3604504) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Clemizole, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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