Structure
ST-2825, Inhibitor
ST-2825
Purity
>98% (HPLC)
Synonyms
ST-2825; ST 2825; ST2825; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
MyD88
Receptor
MyD88
Chemical Name
Spiro[pyrrolidine-2, 7'(6'H)-[2H]pyrrolo[2, 1-b][1, 3]thiazine]-4'-carboxamide, 1-[2-[4-[[2-(2, 4-dichlorophenoxy)acetyl]amino]phenyl]acetyl]tetrahydro-6'-oxo-, (2R, 4'R, 8'aR)
SMILES
O=C([C@@H]1N2[C@](C[C@@]3(N(C(CC4=CC=C(NC(COC5=CC=C(Cl)C=C5Cl)=O)C=C4)=O)CCC3)C2=O)([H])SCC1)N
Molecular Formula
C27H28Cl2N4O5S
CAS Number
894787-30-5
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for ST-2825, inhibitor
A synthetic peptido-mimetic compound that inhibits MyD88 dimerization in a TIR-dependent manner; interferes with recruitment of IRAK1 and IRAK4 by MyD88, causing inhibition of IL-1beta-mediated activation of NF-kappaB transcriptional activity; inhibits IL-1beta-induced production of IL-6 in treated mice, suppresses B cell proliferation and differentiation into plasma cells in response to CpG-induced activation of TLR9; orally active.
Product Categories/Family for ST-2825, inhibitor
References
1. Loiarro M, et al. J Leukoc Biol. 2007 Oct; 82 (4):801-10.
2. Van Tassell BW, et al. Pharmacol. 2011 Feb; 57 (2):272.
3. Capolunghi F, et al. Rheumatology (Oxford). 2010 Dec; 49 (12):2281-9.
2. Van Tassell BW, et al. Pharmacol. 2011 Feb; 57 (2):272.
3. Capolunghi F, et al. Rheumatology (Oxford). 2010 Dec; 49 (12):2281-9.
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Product Notes
The ST-2825 (Catalog #AAA3606440) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "ST-2825, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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