Structure
Ilepatril, Inhibitor
Ilepatril
Purity
>98% (HPLC)
Synonyms
Ilepatril; AVE 7688; AVE7688; inhibitor
Purity/Purification
>98% (HPLC)
Target
ACE
Receptor
ACE
Chemical Name
7-[[(2S)-2-(acetylthio)-1-oxo-3-methylpropyl]amino]-1, 2, 3, 4, 6, 7, 8, 12b-octahydro-6-oxo-(4S, 7S, 12bR)-pyrido[2, 1-a][2]benzazepine-4-carboxic acid
SMILES
CCC(C(=O)NC1CC2=CC=CC=C2C3CCCC(N3C1=O)C(=O)O)SC(=O)C
Molecular Formula
C21H26N2O5S
CAS Number
669764-02-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Ilepatril, inhibitor
A potent, dual ACE-neutral endopeptidase (vasopeptidase) inhibitor with IC50 of 0.053 and 5.0nM, respectively; displays good in vitro selectivity over a large variety of targets; restores endothelial function by increasing the ratio of NO to O2- concentration and bioavailability of NO, prevents albuminuria and reduces the incidence and severity of glomerulosclerosis and tubulointerstitial damage in vivo. Hypertension Phase 2 Discontinued
Product Categories/Family for Ilepatril, inhibitor
References
1. Weckler N, et al. J Renin Angiotensin Aldosterone Syst. 2003 Sep; 4 (3):191-6.
2. Schfer S, et al. Cardiovasc Res. 2003 Nov 1; 60 (2):447-54.
3. Schfer S, et al. Diabetologia. 2004 Jan; 47 (1):98-103.
4. Schfer S, et al. Eur J Pharmacol. 2004 Jan 26; 484 (2-3):361-2.
2. Schfer S, et al. Cardiovasc Res. 2003 Nov 1; 60 (2):447-54.
3. Schfer S, et al. Diabetologia. 2004 Jan; 47 (1):98-103.
4. Schfer S, et al. Eur J Pharmacol. 2004 Jan 26; 484 (2-3):361-2.
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Product Notes
The Ilepatril (Catalog #AAA3605554) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Ilepatril, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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