EB-3D, Inhibitor

EB-3D

Cat. Num. AAA3602841

• Purity: >98% (HPLC)
• Synonyms: EB-3D; ChoK inhibitor EB-3D; inhibitor

• Purity/Purification: >98% (HPLC)

• Target: ChoK
• Receptor: ChoK
• Chemical Name: 1, 1'-(((ethane-1, 2-diylbis(oxy))bis(4, 1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridinium) bromide
• SMILES: CN(C)C1=CC=[N+](C=C1)CC2=CC=C(C=C2)OCCOC3=CC=C(C=C3)C[N+]4=CC=C(C=C4)N(C)C.[Br-].[Br-]
• Molecular Formula: C30H36Br2N4O2
• CAS Number: 1839150-63-8
• Preparation and Storage: Store at -20 degree C; Stability: >=2 years; Shipping: Ice Pack

Structure

Related Product Information for EB-3D, inhibitor

EB-3D is a novel potent and selective choline kinase ChoKalpha inhibitor with IC50 of 1.0uM (purified ChoKalpha1), strongly impairs cell proliferation in a variety of different cancer cell lines; demonstrates in vitro antiproliferative effects against HeLa (IC50=79nM), RS4, 11 (IC50=45nM), A549 (IC50=27nM) and MDA-MB-231 (IC50=100nM); displays excellent antiproliferative activity against a wide cohort of T-leukemic cell lines with GI50 of 0.9nM (MOLT-16 cell)-479nM (CCRF-CEM), reduces the intracellular pool of PCho, but also inhibits the synthesis of choline-containing lipids; induces G0/G1 arrest that lead to apoptosis in leukemia cell lines; affects AMPK-mTOR signaling pathway, synergizes with both dexamethasone and L-asparaginase.

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References

1. Schiaffino-Ortega S, et al. Sci Rep. 2016 Mar 31; 6:23793.
2. Mariotto E, et al. Biochem Pharmacol. 2018 Jul 10. pii: S0006-2952 (18)30272-7.