Structure
CL27c Biochemical
CL27c
Purity
>98% (HPLC)
Synonyms
CL27c; CL27c biochemical
Purity/Purification
>98% (HPLC)
Target
PI3K
Receptor
PI3K
Chemical Name
methyl 3-((4-(2-morpholino-4-oxo-1, 4-dihydroquinolin-8-yl)-1H-1, 2, 3-triazol-1-yl)methyl)benzoate
Molecular Formula
C24H23N5O4
CAS Number
1380227-11-1
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for CL27c biochemical
CL27c is a cell-permeable, inhaled lipophilic ester prodrug of CL27e, which is a potent, selective pan-class I PI3K inhibitor, CL27c is inactive in PI3K enzymatic assay, once inside the cytoplasm, CL27c is metabolized by unspecific esterases into CL27e; readily reduces Akt/PKB phosphorylation in chronic lymphocytic leukemia (CLL) cells stimulated with anti-IgM antibodies, as well as in murine neutrophils and bone marrow-derived macrophages (BMDM) stimulated with C5a; reduces insulin-evoked Akt phosphorylation in lungs, but no change in other tissues and no increase in blood glycaemia, in line with a local action; reduces inflammation and improves lung function in murine models of acute or glucocorticoid-resistant neutrophilic asthma.
Product Categories/Family for CL27c biochemical
References
1. Campa CC, et al. Nat Commun. 2018 Dec 12; 9 (1):5232.
2. Pirali T, et al. ChemMedChem. 2017 Sep 21; 12 (18):1542-1554.
2. Pirali T, et al. ChemMedChem. 2017 Sep 21; 12 (18):1542-1554.
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Product Notes
The CL27c (Catalog #AAA3601569) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CL27c, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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