Structure
SKI-2852, Inhibitor
SKI-2852
Purity
>98% (HPLC)
Synonyms
SKI-2852; SKI 2852; SKI2852; inhibitor
Purity/Purification
>98% (HPLC)
Target
11beta-HSD
Receptor
11beta-HSD
Chemical Name
2-((R)-4-(2-Fluoro-4-(methylsulfonyl)phenyl)-2-methylpiperazin-1-yl)-N-((1R, 2s, 3S, 5S, 7S)-5-hydroxyadamantan-2-yl)pyrimidine-4-carboxamide
SMILES
O=C(C1=NC(N2CCN(C[C@H]2C)C3=CC=C(C=C3F)S(C)(=O)=O)=NC=C1)N[C@@H]4[C@@H]5C[C@H]6C[C@](C5)(O)C[C@@H]4C6
Molecular Formula
C27H34FN5O4S
CAS Number
1346554-47-9
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for SKI-2852, inhibitor
A highly potent, selective, and orally bioavailable 11beta-HSD1 inhibitor with IC50 of 2.9 and 1.6nM for hHSD1 and mHSD1, respectively; demonstrates no CYP and PXR liabilities, excellent PK profiles across species, and highly potent and sustainable PD activity; significantly reduces blood glucose and HbA1c levels and improves the lipid profiles in ob/ob mice, synergistically enhances the HbA1c-lowering effect of metformin in vivo.
Product Categories/Family for SKI-2852, inhibitor
References
1. Ryu JH, et al. J Med Chem. 2016 Nov 23; 59 (22):10176-10189.
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Product Notes
The SKI-2852 (Catalog #AAA3601401) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "SKI-2852, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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