Structure
(-) BI97D6, Inhibitor
(-) BI97D6
Purity
>98% (HPLC)
Synonyms
(-) BI97D6; BI97D6; inhibitor
Purity/Purification
>98% (HPLC)
Target
Bcl-2
Receptor
Bcl-2
Chemical Name
5, 5'-dibenzyl-6, 6', 7, 7'-tetrahydroxy-3, 3'-dimethyl-[2, 2'-binaphthalene]-1, 1', 4, 4'-tetraone
Molecular Formula
C36H26O8
CAS Number
1256724-10-3
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for (-) BI97D6, inhibitor
(-) BI97D6 (BI112D1) is a potent, pan-active inhibitor of Bcl-2 family proteins with IC50 of 76, 31, 25, and 122nM for Bcl-xL, Bcl-2, Mcl-1, and Bfl-1, respectively; effectively inhibits cell growth in the PC-3 human prostate cancer and H23 human lung cancer cell lines with EC50 of 0.22 and 0.14uM, respectively; effectively induces apoptosis in the BP3 human lymphoma cell line; displays in vivo efficacy in a prostate cancer xenograft model in mice; also overcomes ABT-737 resistance in AML, kills AML leukemia stem/progenitor cells while largely sparing normal hematopoietic stem/progenitor cells.
Product Categories/Family for (-) BI97D6, inhibitor
References
1. Wei J, et al. Front Oncol. 2011 Sep 30; 1:28.
2. Pan R, et al. Blood. 2015 Jul 16; 126 (3):363-72.
3. Wei J, et al. J Med Chem. 2009 Jul 23; 52 (14):4511-23.
2. Pan R, et al. Blood. 2015 Jul 16; 126 (3):363-72.
3. Wei J, et al. J Med Chem. 2009 Jul 23; 52 (14):4511-23.
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Product Notes
The (-) BI97D6 (Catalog #AAA3601053) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "(-) BI97D6, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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