Structure
Apogossypol, Inhibitor
Apogossypol
Purity
>98% (HPLC)
Synonyms
Apogossypol; (+)-Apogossypol; NSC 736630; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
Bcl-2
Receptor
Bcl-2
Chemical Name
[2, 2'-Binaphthalene]-1, 1', 6, 6', 7, 7'-hexol, 3, 3'-dimethyl-5, 5'-bis(1-methylethyl)-, (2S)
SMILES
CC1=CC2=C(C(=C(C=C2C(=C1C3=C(C4=CC(=C(C(=C4C=C3C)C(C)C)O)O)O)O)O)O)C(C)C
Molecular Formula
C28H30O6
CAS Number
66389-74-0
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Apogossypol, inhibitor
Apogossypol (NSC 736630) is a Bcl-2 family antagonist that binds to Bcl-XL, Bcl-2 and Bcl-xL with IC50 of 2.6, 2.8 and 3.69uM, respectively; induces apoptosis of tumor cell lines, inhibits the growth and proliferation of prostate cancer cells by downregulating Bcl2 protein expression and activating caspase3 and 8; displays superior activity to gossypol in terms of reducing splenomegaly and reducing B-cell counts in spleens of Bcl-2-transgenic mice.
Product Categories/Family for Apogossypol, inhibitor
References
1. Becattini B, et al. Chem Biol. 2004 Mar; 11 (3):389-95.
2. Wei J, et al. Mol Cancer Ther. 2009 Apr; 8 (4):904-13.
3. Kitada S, et al. Blood. 2008 Mar 15; 111 (6):3211-9.
4. Zhan W, et al. Mol Med Rep. 2015 Jun; 11 (6):4142-8.
2. Wei J, et al. Mol Cancer Ther. 2009 Apr; 8 (4):904-13.
3. Kitada S, et al. Blood. 2008 Mar 15; 111 (6):3211-9.
4. Zhan W, et al. Mol Med Rep. 2015 Jun; 11 (6):4142-8.
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Product Notes
The Apogossypol (Catalog #AAA3605528) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Apogossypol, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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