Structure
GNE-220, Inhibitor
GNE-220
Purity
>98% (HPLC)
Synonyms
GNE-220; GNE220; inhibitor
Purity/Purification
>98% (HPLC)
Target
MAP4K
Receptor
MAP4K
Chemical Name
4-Methyl-8-[4-(4-methyl-1-piperazinyl)phenyl]-2-(1-methyl-1H-pyrazol-4-yl)-5H-pyrido[3', 2':4, 5]pyrrolo[3, 2-d]pyrimidine
SMILES
CC1=C2C(=NC(=N1)C3=CN(N=C3)C)C4=C(N2)N=CC(=C4)C5=CC=C(C=C5)N6CCN(CC6)C
Molecular Formula
C25H26N8
CAS Number
1199590-75-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for GNE-220, inhibitor
GNE-220 is a potent and selective inhibitor of MAP4K4 with IC50 of 7nM, also inhibits MINK (MAP4K6), DMPK and KHS1 (MAP4K5) with IC50 of 9nM, 476nM and 1, 110nM; alters HUVEC sprout morphology, shifts the distribution of subcellular protrusion and increases total protrusions, dose-dependently increases the number of beta1-integrin in long focal adhesions.
Product Categories/Family for GNE-220, inhibitor
References
1. Vitorino P, et al. Nature. 2015 Mar 26; 519 (7544):425-30.
2. Gao X, et al. Cell Biosci. 2016 Oct 28; 6:56. eCollection 2016.
2. Gao X, et al. Cell Biosci. 2016 Oct 28; 6:56. eCollection 2016.
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Product Notes
The GNE-220 (Catalog #AAA3600715) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "GNE-220, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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