Structure
DSP-1053, Inhibitor
DSP-1053
Purity
>98% (HPLC)
Synonyms
DSP-1053; DSP1053; inhibitor
Purity/Purification
>98% (HPLC)
Target
5-HT Receptor
Receptor
5-HT Receptor
Chemical Name
6-(2-{4-[4-Bromo-3-(2-methoxyethoxy)benzyl]piperidin-1-yl}ethyl)-2, 3-dihydro-4H-chromen-4-one benzenesulfonate
Molecular Formula
C32H38BrNO7S
CAS Number
1176326-78-5
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for DSP-1053, inhibitor
DSP-1053 is a novel potent serotonin reuptake (SERT) inhibitor with 5-HT1A partial agonistic activity that binds to human serotonin transporter and 5-HT1A receptor with Ki of 1.02 and 5.05nM, respectively; inhibits serotonin transporter with IC50 of 2.74nM and shows an intrinsic activity for 5-HT1A receptors of 70.0%; dose-dependently increases extracellular 5-HT levels in rat microdialysis at 3-10mg/kg, demonstrates antidepressant-like effect in vivo. Depression Phase 1 Discontinued
Product Categories/Family for DSP-1053, inhibitor
References
1. Yoshinaga H, et al. Bioorg Med Chem. 2018 May 1; 26 (8):1614-1627.
2. Kato T, et al. Pharmacol Res Perspect. 2015 Jun; 3 (3):e00142.
2. Kato T, et al. Pharmacol Res Perspect. 2015 Jun; 3 (3):e00142.
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Product Notes
The DSP-1053 (Catalog #AAA3600599) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "DSP-1053, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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