IFN beta 1b active protein
IFN beta 1b Protein (Active)
Applications
SDS-Page
Synonyms
IFN beta 1b; IFN beta 1b Protein (Active); Leukocyte interferon; B cell interferon; Type I interferon; IFNB1; IFB; IFF; IFNB; IFN-b 1b; Interferon beta 1b; INFbeta 1b Protein (Active); INFb 1b Protein (Active); IFN beta 1b active protein
Host
E Coli
Form/Format
Lyophilized
Applicable Applications for IFN beta 1b active protein
SDS-PAGE
Biological Activity
In a viral resistance assay using monkey VERO cell line with EMCV virus is < 3×107 IU/mg.
Dimers
< 1% by SDS-PAGE
Endotoxin Level
< 0.1 ng/ug (1 EU/ug) by LAL test
Reconstitution
Reconstitute with sterile 18MΩ-cm H2O.
Storage Buffer
Each vial contains 10 mM Phosphate buffer and 200 mM NaCl (pH7.0) without preservatives.
Storage Buffer
Each vial contains 10 mM Phosphate buffer and 200 mM NaCl (pH7.0) without preservatives.
Preparation and Storage
Ship at 4 degree C. Upon receipt, store at -20 degree C or -80 degree C for 2 years. After reconstituting, it can store at 4 degree C for a week, it is recommended to add 0.1% HSA or BSA for long term. Avoid repeated freeze and thaw cycles
Related Product Information for IFN beta 1b active protein
Recombinant human INFbeta 1b protein with molecular weight 19 kDa.
Fibroblast interferon, or interferon-beta has 45% homology at the nucleotide level and 29% at the amino acid level with leukocyte interferon, or interferon-alpha. RANKL induces the IFN-beta gene in osteoclast precursor cells, and that IFN-beta inhibits the differentiation of osteoclasts by interfering with the RANKL-induced expression of c-Fos, an essential transcription factor for the formation of osteoclasts. This IFN-beta gene induction mechanism is distinct from that induced by virus, and is dependent on c-Fos itself.
Fibroblast interferon, or interferon-beta has 45% homology at the nucleotide level and 29% at the amino acid level with leukocyte interferon, or interferon-alpha. RANKL induces the IFN-beta gene in osteoclast precursor cells, and that IFN-beta inhibits the differentiation of osteoclasts by interfering with the RANKL-induced expression of c-Fos, an essential transcription factor for the formation of osteoclasts. This IFN-beta gene induction mechanism is distinct from that induced by virus, and is dependent on c-Fos itself.
References
1. Taniguchi, T., Fujii-Kuriyama, Y., Muramatsu, M. Molecular cloning of human interferon cDNA. Proc. Nat. Acad. Sci. 77: 4003-4006, 1980. 2. Takayanagi, H., Kim, S., Matsuo, K., Suzuki, H., Suzuki, T., Sato, K., Yokochi, T., Oda, H., Nakamura, K., Ida, N., Wagner, E. F., Taniguchi, T. RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-B. Nature 416: 744-749, 2002.
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Product Notes
The IFN beta 1b (Catalog #AAA355576) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's IFN beta 1b can be used in a range of immunoassay formats including, but not limited to, SDS-PAGE. Researchers should empirically determine the suitability of the IFN beta 1b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IFN beta 1b, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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