Mouse anti-Human IL-15 Monoclonal Antibody | anti-IL-15 antibody
Mouse Anti-Human IL-15 Monoclonal Antibody, Azide Free Clone B-E29
Reactivity
Human
Applications
Flow Cytometry, Functional Assay, ELISA, Functional Assay
Synonyms
IL-15; Monoclonal Antibody; Mouse Anti-Human IL-15 Monoclonal Antibody; Azide Free Clone B-E29; anti-IL-15 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
Mouse IgG1 kappa light chain
Clone Number
B-E29
Specificity
Recognises both natural and recombinant human IL-15
Form/Format
Phosphate-buffered saline. Sterile-filtered through 0.22 um and treated to remove endotoxins. Carrier and preservative free
Sequence Length
162
Applicable Applications for anti-IL-15 antibody
Flow Cytometry (FC/FACS), ELISA (EIA), Functional Assay
Application Notes
Blocks IL-15 induced proliferation on Kit 225 cell line
Antigen
IL-15
Hybridoma
Myeloma X63/AG.8653 x Balb/c spleen cells
Immunisation
Recombinant human IL-15
Preparation and Storage
Store at +2-8 degree C for 12 months. For longer storage, freeze aliquots.
Related Product Information for anti-IL-15 antibody
Interleukin-15 (IL-15) is a glycoprotein of 14-15 kDa which was originally found in conditioned medium of a Rhesus monkey kidney epithelial cell line, CV-1/EBNA. IL-15 has been shown to be structurally similar to IL-2. IL-15 is mainly synthesized by macrophage/monocytes and other non-lymphoid cells. This cytokine exerts its effects through its binding to a membrane receptor composed of a private a chain (IL-15Ra) associated with the b chain of IL-2R and the common g subunit of different type I cytokine receptors. As expected, IL-2 and IL-15 share several effects such as the activation of NK cells, the induction of CD8+ T cell proliferation and the costimulation of B-cell proliferation and differentiation. However, IL-15 has additional effects, including the induction of T-cell polarization, differentiation of dendritric cells, inhibition of apoptosis of lymphoid cells and activation of polymorphonuclear leucocytes (PMNs). IL-15 synthesis is mainly regulated at a post-transcriptional level, and different stimuli, including LPS and cytokines (IFNg, TNFa) efficiently induce its production and release. IL-15 has a key role in the pathogenesis of inflammatory and malignant diseases. Abnormalities of IL-15 expression have been described in patients with rheumatoid arthritis or inflammatory bowel disease and in diseases associated with the retrovirus HIV and HTLV.
References
Bernard et.al J Biol Chem 2004
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
interleukin-15
NCBI Official Synonym Full Names
interleukin 15
NCBI Official Symbol
Il15
NCBI Protein Information
interleukin-15
UniProt Protein Name
Interleukin-15
UniProt Gene Name
Il15
UniProt Synonym Gene Names
IL-15
UniProt Entry Name
IL15_RAT
NCBI Description
human homolog is a cytokine involved in the regulation of T and natural killer cell activation and proliferation [RGD, Feb 2006]
Uniprot Description
Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha ().
Research Articles on IL-15
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Product Notes
The IL-15 il15 (Catalog #AAA335170) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Anti-Human IL-15 Monoclonal Antibody, Azide Free Clone B-E29 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's IL-15 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS), ELISA (EIA), Functional Assay. Blocks IL-15 induced proliferation on Kit 225 cell line. Researchers should empirically determine the suitability of the IL-15 il15 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IL-15, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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