GEMIN2 blocking peptide
GEMIN2 Peptide - middle region
NCBI and Uniprot Product Information
NCBI Description
This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. [provided by RefSeq, Aug 2011]
Uniprot Description
SIP1: The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. Belongs to the gemin-2 family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: RNA splicing
Chromosomal Location of Human Ortholog: 14q13
Cellular Component: nucleoplasm; spliceosome; cytoplasm; nucleolus; SMN complex; cytosol; nucleus
Molecular Function: protein binding
Biological Process: RNA splicing, via transesterification reactions; spliceosomal snRNP biogenesis; RNA splicing; spliceosome assembly; gene expression; mRNA processing
Research Articles on GEMIN2
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Product Notes
The GEMIN2 gemin2 (Catalog #AAA3245988) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The GEMIN2 Peptide - middle region reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: Synthetic peptide located within the following region: QQQQVAQFST VRQNVNKHRS HWKSQQLDSN VTMPKSEDEE GWKKFCLGEK. It is sometimes possible for the material contained within the vial of "GEMIN2, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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