RPRD1B blocking peptide
RPRD1B Peptide - middle region
Target Description: The function of this protein remains unknown.
NCBI and Uniprot Product Information
Uniprot Description
RPRD1B: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation. Belongs to the UPF0400 (RTT103) family.
Protein type: Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 20q11.23
Cellular Component: centrosome; cytoplasm; DNA-directed RNA polymerase II, holoenzyme; nucleoplasm; nucleus
Molecular Function: protein binding
Biological Process: positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; snRNA transcription from RNA polymerase II promoter
Research Articles on RPRD1B
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Product Notes
The RPRD1B rprd1b (Catalog #AAA3238358) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The RPRD1B Peptide - middle region reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's RPRD1B can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the RPRD1B rprd1b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: KKSLKRTFQQ IQEEEDDDYP GSYSPQDPSA GPLLTEELIK ALQDLENAAS. It is sometimes possible for the material contained within the vial of "RPRD1B, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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