TAF2 blocking peptide

TAF2 Peptide - middle region

Cat. Num. AAA3226509

• Gene Names: TAF2; MRT40; TAF2B; CIF150; TAFII150
• Applications: Chromatin Immunoprecipitation, Immunoprecipitation, Western Blot
• Synonyms: TAF2; TAF2 Peptide - middle region; TAF2 blocking peptide

• Form/Format: Lyophilized powder
• Sequence Length: 1199

• Applicable Applications for TAF2 blocking peptide: Chromatin IP (ChIP), Western Blot (WB)
• Preparation and Storage: Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.

Related Product Information for TAF2 blocking peptide

This is a synthetic peptide designed for use in combination with anti-TAF2 antibody made

Target Description: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. TAF2 is one of the larger subunits of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators.Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Product Categories/Family for TAF2 blocking peptide

Peptide

NCBI and Uniprot Product Information

• NCBI GI #: 1519316338
• NCBI GeneID: 6873
• NCBI Accession #: NP_003175
• NCBI GenBank Nucleotide #: NM_003184
• UniProt Accession #: Q6P1X5
• Molecular Weight: 137kDa
• NCBI Official Full Name: transcription initiation factor TFIID subunit 2
• NCBI Official Synonym Full Names: TATA-box binding protein associated factor 2
• NCBI Official Symbol: TAF2
• NCBI Official Synonym Symbols: MRT40; TAF2B; CIF150; TAFII150
• NCBI Protein Information: transcription initiation factor TFIID subunit 2
• UniProt Protein Name: Transcription initiation factor TFIID subunit 2
• Protein Family: Transcription initiation factor
• UniProt Gene Name: TAF2
• UniProt Synonym Gene Names: CIF150; TAF2B; TAF(II)150; TAFII-150; TAFII150
• UniProt Entry Name: TAF2_HUMAN

NCBI Description

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators. [provided by RefSeq, Jul 2008]

Uniprot Description

TAF2: Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. It requires core promoter-specific cofactors for productive transcription stimulation. TAF2 stabilizes TFIID binding to core promoter. Belongs to the TAF2 family.

Protein type: Transcription initiation complex

Chromosomal Location of Human Ortholog: 8q24.12

Cellular Component: nucleoplasm; transcription factor TFIID complex

Molecular Function: protein binding; zinc ion binding; metallopeptidase activity

Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; viral reproduction; RNA elongation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; gene expression; proteolysis; G2/M transition of mitotic cell cycle; response to organic cyclic substance

Disease: Mental Retardation, Autosomal Recessive 40