Western Blot (WB)
(WB Suggested Anti-Loxl2 AntibodyTitration: 1.0 ug/mlPositive Control: Mouse Heart)
Rabbit Loxl2 Polyclonal Antibody | anti-LOXL2 antibody
Loxl2 antibody - C-terminal region
Western Blot (WB)
(WB Suggested Anti-Loxl2 AntibodyTitration: 1.0 ug/mlPositive Control: Mouse Heart)
Western Blot (WB)
(WB Suggested Anti-Loxl2 AntibodyTitration: 1.0 ug/mlPositive Control: Mouse Heart)
Target Description: The function of this protein remains unknown.
NCBI and Uniprot Product Information
Uniprot Description
LOXL2: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E- cadherin, probably by mediating deamination of histone H3. Also involved in E-cadherin repression following hypoxia, a hallmark of epithelial to mesenchymal transition believed to amplify tumor aggressiveness, suggesting that it may play a role in tumor progression. Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation. Belongs to the lysyl oxidase family.
Protein type: Oxidoreductase; EC 1.4.3.13; Cell adhesion; Secreted; Secreted, signal peptide
Cellular Component: basement membrane; chromosome; extracellular region; extracellular space; membrane; nucleoplasm; nucleus; proteinaceous extracellular matrix
Molecular Function: chromatin binding; copper ion binding; metal ion binding; methylated histone residue binding; oxidoreductase activity; oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor; protein-lysine 6-oxidase activity; scavenger receptor activity; transcription corepressor activity
Biological Process: chromatin modification; collagen fibril organization; endothelial cell migration; endothelial cell proliferation; epithelial to mesenchymal transition; histone modification; negative regulation of transcription, DNA-dependent; positive regulation of chondrocyte differentiation; protein amino acid deamination; protein modification process; regulation of transcription, DNA-dependent; response to copper ion; response to hypoxia; sprouting angiogenesis; transcription, DNA-dependent
Research Articles on LOXL2
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Product Notes
The LOXL2 loxl2 (Catalog #AAA3211805) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Loxl2 antibody - C-terminal region reacts with Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish and may cross-react with other species as described in the data sheet. AAA Biotech's Loxl2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the LOXL2 loxl2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: NNGQSDFRPK NGRHAWIWHD CHRHYHSMEV FTYYDLLSLN GTKVAEGHKA. It is sometimes possible for the material contained within the vial of "Loxl2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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