Western Blot (WB)
(WB Suggested Anti-KCNIP2 AntibodyTitration: 1.0 ug/mlPositive Control: 293T Whole Cell)
Rabbit KCNIP2 Polyclonal Antibody | anti-KCNIP2 antibody
KCNIP2 antibody - C-terminal region
Western Blot (WB)
(WB Suggested Anti-KCNIP2 AntibodyTitration: 1.0 ug/mlPositive Control: 293T Whole Cell)
Western Blot (WB)
(WB Suggested Anti-KCNIP2 AntibodyTitration: 1.0 ug/mlPositive Control: 293T Whole Cell)
Target Description: KCNIP2 encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
KCNIP2: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. Belongs to the recoverin family. 9 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 10q24
Cellular Component: voltage-gated potassium channel complex; cytoplasm
Molecular Function: identical protein binding; protein binding; potassium channel regulator activity; protein N-terminus binding; calcium ion binding; ER retention sequence binding; A-type (transient outward) potassium channel activity
Biological Process: synaptic transmission; muscle contraction; clustering of voltage-gated potassium channels; detection of calcium ion; signal transduction; regulation of heart contraction; potassium ion transport
Research Articles on KCNIP2
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Product Notes
The KCNIP2 kcnip2 (Catalog #AAA3202609) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The KCNIP2 antibody - C-terminal region reacts with Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's KCNIP2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the KCNIP2 kcnip2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: DLNKDGCITK EEMLDIMKSI YDMMGKYTYP ALREEAPREH VESFFQKMDR. It is sometimes possible for the material contained within the vial of "KCNIP2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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