Natriuretic Peptide Receptor B (NPR-B) (a.a. 288-302) Peptide | NPR2 peptide

Human NPR-B (a.a. 288-302) Peptide

Cat. Num. AAA318033

• Gene Names: NPR2; AMDM; ANPb; NPRB; ANPRB; GUC2B; NPRBi; GUCY2B
• Purity: >95% pure (HPLC)
• Synonyms: Natriuretic Peptide Receptor B (NPR-B) (a.a. 288-302); Human NPR-B (a.a. 288-302) Peptide; Human Natriuretic Peptide Receptor B (NPR-B) (amino acids 288-302); NPR2 peptide

• Host: Synthetic human NPR-B (a.a. 288-302) peptide, (QNRLLIRAREDFGVE)
• Specificity: Natriuretic Peptide Receptor B (NPR-B) (a.a. 288-302)
• Purity/Purification: >95% pure (HPLC)
• Form/Format: Purified, Lyophilized.,Reconstitute in 0.1% acetic acid.
• Sequence Length: 1047

• Inactivation: Not applicable.
• Buffer: Not applicable.
• Preservative: No
• Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
• Lyophilized: Yes
• Preparation and Storage: Store at -20 degree C.

Product Categories/Family for NPR2 peptide

Purified Cardiac Markers

NCBI and Uniprot Product Information

• NCBI GI #: 4580422
• NCBI GeneID: 4882
• NCBI Accession #: NP_003986.2
• NCBI GenBank Nucleotide #: NM_003995.3
• UniProt Accession #: P20594; O60871; Q4VAK7; Q5TCV2; Q8TA93; Q9UQ50; B0ZBF2; B0ZBF3; D3DRP3; D3DRP4
• Molecular Weight: 117,022 Da
• NCBI Official Full Name: atrial natriuretic peptide receptor 2
• NCBI Official Synonym Full Names: natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
• NCBI Official Symbol: NPR2
• NCBI Official Synonym Symbols: AMDM; ANPb; NPRB; ANPRB; GUC2B; NPRBi; GUCY2B
• NCBI Protein Information: atrial natriuretic peptide receptor 2; GC-B; ANP-B; NPR-B; ANPR-B; OTTHUMP00000021345; guanylate cyclase B; atrial natriuretic peptide B-type receptor; atrial natriuretic peptide receptor type B
• UniProt Protein Name: Atrial natriuretic peptide receptor 2
• Protein Family: Nitrogen permease regulator
• UniProt Gene Name: NPR2
• UniProt Synonym Gene Names: ANPRB
• UniProt Entry Name: ANPRB_HUMAN

NCBI Description

This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq]

Uniprot Description

Function: Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth. Ref.9 Ref.11

Catalytic activity: GTP = 3',5'-cyclic GMP + diphosphate.

Subcellular location: Membrane; Single-pass type I membrane protein.

Post-translational modification: Phosphorylation of the protein kinase-like domain is required for full activation by CNP

Involvement in disease: Defects in NPR2 are the cause of acromesomelic dysplasia Maroteaux type (AMDM) [

MIM:602875]. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs, and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers). AMDM is an autosomal recessive form characterized by axial skeletal involvement with wedging of vertebral bodies. In AMDM all skeletal elements are present but show abnormal rates of linear growth. Ref.11

Sequence similarities: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.Contains 1 guanylate cyclase domain.Contains 1 protein kinase domain.