Rabbit GPR190 Polyclonal Antibody | anti-GPR190 antibody

GPR190 polyclonal antibody

Cat. Num. AAA3014880

• Gene Names: MOV10L1; CHAMP; DJ402G11.8
• Reactivity: Human, Rat, Mouse
• Applications: Western Blot, Immunohistochemistry
• Purity: The protein was purified from E Coli and the purity is >95% (by SDS-PAGE)
• Synonyms: GPR190; Polyclonal Antibody; GPR190 polyclonal antibody; RNA helicase Mov10l1; Moloney leukemia virus 10-like protein 1; MOV10-like protein 1; MOV10L1; anti-GPR190 antibody

• Host: Rabbit
• Reactivity: Human, Rat, Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: MOV10L1 polyclonal antibody detects endogenous levels of MOV10L1 protein.
• Purity/Purification: The protein was purified from E Coli and the purity is >95% (by SDS-PAGE)
• Form/Format: PBS with 0.02% sodium azide, 50% glycerol, pH7.4
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-GPR190 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:500~1000
• Immunogen: Synthetic peptide, corresponding to Human MOV10L1
• Preparation and Storage: Store at 4 degree C short term. Aliquot and store at -25 degree C long term. Avoid freeze-thaw cycles.

Western Blot (WB)

(Western blot (WB) analysis of MOV10L1 polyclonal antibody at 1:500 dilutionLaneA: The testis tissue lysate of RatLaneB: The testis tissue lysate of Mouse)

Related Product Information for anti-GPR190 antibody

MOV10 is a RNA helicase that is required for RNA-mediated gene silencing by RISC (RNA-induced silencing complex). Significantly, MOV10 is also required for the transcription and replication of the human hepatitis delta virus, also known as hepatitis D. Belonging to the same family as MOV10, MOV10L1 (moloney leukemia virus 10-like protein 1) is a 1,211 amino acid RNA helicase that is expressed as three isoforms. Interestingly, isoform 1 is expressed exclusively in testis and isoform 2 is specifically expressed in cardiac myocytes. Isoform 1 may play a role in male germ cell development, isoform 2 has been shown to potentiate phenylephrine-induced hypertrophic response in cardiomyocytes. Each isoform contains a RNA interaction motif, ATP binding site and helicase motif through which it carries out its function.

NCBI and Uniprot Product Information

• NCBI GI #: 255759906
• NCBI GeneID: 54456
• NCBI Accession #: NP_001157576.1
• NCBI GenBank Nucleotide #: NM_001164104.1
• UniProt Accession #: Q9BXT6; Q5TGD5; Q8NBD4; Q9NXW3; Q9UFB3; Q9UGX9; A7E211; A8MXC6; B7WPP1; B7Z7R1; F5H403
• Molecular Weight: 135,293 Da
• NCBI Official Full Name: putative helicase Mov10l1 isoform 2
• NCBI Official Synonym Full Names: Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)
• NCBI Official Symbol: MOV10L1
• NCBI Official Synonym Symbols: CHAMP; DJ402G11.8
• NCBI Protein Information: putative helicase Mov10l1; Mov10-like 1; MOV10-like protein 1; moloney leukemia virus 10-like protein 1; cardiac helicase activated by MEF2C protein
• UniProt Protein Name: Putative helicase Mov10l1
• UniProt Gene Name: MOV10L1
• UniProt Synonym Gene Names: MOV10-like protein 1
• UniProt Entry Name: M10L1_HUMAN

NCBI Description

This gene is similar to a mouse gene that encodes a putative RNA helicase and shows testis-specific expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

Uniprot Description

MOV10L1: Putative RNA helicase. Isoform 1 may play a role in male germ cell development. Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Helicase; EC 3.6.4.13

Chromosomal Location of Human Ortholog: 22q13.33

Cellular Component: intracellular

Molecular Function: RNA binding; magnesium ion binding; ATP binding; ATP-dependent RNA helicase activity

Biological Process: multicellular organismal development; spermatogenesis; gene expression; germ cell development