Rabbit CSP Polyclonal Antibody | anti-CSP antibody

CSP polyclonal antibody

Cat. Num. AAA3014812

• Gene Names: DNAJC5; CSP; NCL; CLN4; CLN4B; DNAJC5A
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE)
• Synonyms: CSP; Polyclonal Antibody; CSP polyclonal antibody; NCL; CLN4; CLN4B; DNAJC5A; mir-941-2; mir-941-3; mir-941-4; mir-941-5; anti-CSP antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: CSP polyclonal antibody detects endogenous levels of CSP protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE)
• Form/Format: PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-CSP antibody: Western Blot (WB)
• Application Notes: WB: 1:500~1:1000; IHC: 1:50~1:200
• Immunogen: Synthetic peptide, corresponding to Human CSP
• Preparation and Storage: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Western Blot (WB)

(Western blot (WB) analysis of CSP polyclonal antibody at 1:500 dilutionLaneA: AML-12 whole cell lysateLaneB: PMVEC whole cell lysateLaneC: A549 whole cell lysateLaneD: L02 whole cell lysateLaneE: H1792 whole cell lysate)

Related Product Information for anti-CSP antibody

This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70kDa heat shock proteins. The encoded protein plays a role in membrane trafficking and protein folding, and has been shown to have anti-neurodegenerative properties. The encoded protein is known to play a role in cystic fibrosis and Huntington's disease. A pseudogene of this gene is located on the short arm of chromosome 8.

NCBI and Uniprot Product Information

• NCBI GI #: 45504382
• NCBI GeneID: 80331
• NCBI Accession #: NP_079495.1
• NCBI GenBank Nucleotide #: NM_025219.2
• UniProt Accession #: Q9H3Z4; Q9H3Z5; Q9H7H2; A8K0M0; B3KY68; E1P5G8
• Molecular Weight: 22,149 Da
• NCBI Official Full Name: dnaJ homolog subfamily C member 5
• NCBI Official Synonym Full Names: DnaJ (Hsp40) homolog, subfamily C, member 5
• NCBI Official Symbol: DNAJC5
• NCBI Official Synonym Symbols: CSP; NCL; CLN4; CLN4B; DNAJC5A
• NCBI Protein Information: dnaJ homolog subfamily C member 5; cysteine string protein alpha
• UniProt Protein Name: DnaJ homolog subfamily C member 5
• Protein Family: Cold shock protein
• UniProt Gene Name: DNAJC5
• UniProt Synonym Gene Names: CSP; CSP
• UniProt Entry Name: DNJC5_HUMAN

NCBI Description

This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. The encoded protein plays a role in membrane trafficking and protein folding, and has been shown to have anti-neurodegenerative properties. The encoded protein is known to play a role in cystic fibrosis and Huntington's disease. A pseudogene of this gene is located on the short arm of chromosome 8. [provided by RefSeq, Nov 2010]

Uniprot Description

DNAJC5: a cysteine string protein that inhibits N-type calcium channels which is blocked by huntingtin mutants. May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings. Modulates the maturation of cystic fibrosis transmembrane conductance regulator. Two splice-variant isoforms have been described.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 20q13.33

Cellular Component: synaptic vesicle; membrane; mitochondrion; lysosomal membrane; plasma membrane; melanosome

Molecular Function: ATP-dependent protein binding; glycoprotein binding

Biological Process: regulated secretory pathway; synaptic transmission; synaptic vesicle exocytosis; exocytosis; neurotransmitter secretion; negative regulation of neuron apoptosis