Rabbit NKIRAS1 Polyclonal Antibody | anti-NKIRAS1 antibody

NKIRAS1 polyclonal antibody

Cat. Num. AAA3013753

• Gene Names: NKIRAS1; KBRAS1; kappaB-Ras1
• Reactivity: Human, Mouse, Rat, Dog, Pig, Horse, Rabbit
• Applications: Western Blot
• Purity: affinity purified by Protein A
• Synonyms: NKIRAS1; Polyclonal Antibody; NKIRAS1 polyclonal antibody; 2400004O09Rik; I kappa B interacting Ras like protein 1; I-kappa-B-interacting Ras-like protein 1; Kappa B Ras 1; Kappa B Ras protein 1; Kappa B-Ras protein 1; KappaB Ras1; KappaB-Ras1; KBRAS 1; KBRAS1; KBRS1_HUMAN; NF kappa B inhibitor interacting Ras like protein 1; NF-kappa-B inhibitor-interacting Ras-like protein 1; NFKB inhibitor interacting Ras like 1; NFKB inhibitor interacting Ras like protein 1; NKIRAS 1; nkiras1; anti-NKIRAS1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat, Dog, Pig, Horse, Rabbit
• Clonality: Polyclonal
• Specificity: NKIRAS1 polyclonal Antibody detects endogenous levels of NKIRAS1 protein.
• Purity/Purification: affinity purified by Protein A
• Form/Format: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

• Applicable Applications for anti-NKIRAS1 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-2000
• Immunogen: KLH conjugated synthetic peptide derived from human NKIRAS1:131-192/192
• Preparation and Storage: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Testing Data

(Anti-NKIRAS1 at 1/1000 dilution)

Related Product Information for anti-NKIRAS1 antibody

Small guanosine triphosphatases, typified by the mammalian Ras proteins, play major roles in the regulation of numerous cellular pathways. IkappaBinteracting Ras-like proteins, kappaB-Ras1 and kappaB-Ras2, belong to a subclass of evolutionarily conserved Ras-like proteins that differ from other Ras proteins in containing amino acids at positions 12 and 61 that are similar to those present in the oncogenic forms of Ras. These Ras-like proteins, kappaB-Ras1 and kappaB-Ras2, interact with the PEST domains of IkappaBa and IkappaBb and decreasetheir rate of degradation. kappaB-Ras2 shows 71% identity to kappaB-Ras1. In cells,kappaB-Ras proteins are associated only with NFkappaB:IkappaBb complexes and therefore may provide an explanation for the slower rate of degradation of IkappaBb compared with IkappaBa.

NCBI and Uniprot Product Information

• NCBI GI #: 9966809
• NCBI GeneID: 28512
• NCBI Accession #: NP_065078.1
• NCBI GenBank Nucleotide #: NM_020345.3
• UniProt Accession #: Q9NYS0; Q96K18
• Molecular Weight: 21,643 Da
• NCBI Official Full Name: NF-kappa-B inhibitor-interacting Ras-like protein 1
• NCBI Official Synonym Full Names: NFKB inhibitor interacting Ras-like 1
• NCBI Official Symbol: NKIRAS1
• NCBI Official Synonym Symbols: KBRAS1; kappaB-Ras1
• NCBI Protein Information: NF-kappa-B inhibitor-interacting Ras-like protein 1; I-kappa-B-interacting Ras-like protein 1; NFKB inhibitor interacting Ras-like protein 1; kappa B-Ras protein 1; kappa B-ras 1
• UniProt Protein Name: NF-kappa-B inhibitor-interacting Ras-like protein 1
• Protein Family: NF-kappa-B inhibitor-interacting Ras-like protein
• UniProt Gene Name: NKIRAS1
• UniProt Synonym Gene Names: KBRAS1; Kappa B-Ras protein 1; KappaB-Ras1
• UniProt Entry Name: KBRS1_HUMAN

Uniprot Description

NKIRAS1: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB. Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

Protein type: G protein; G protein, monomeric; G protein, monomeric, Ras

Chromosomal Location of Human Ortholog: 3p24.2

Cellular Component: membrane; cytoplasm

Molecular Function: GTPase activity; GTP binding

Biological Process: I-kappaB kinase/NF-kappaB cascade; metabolic process; small GTPase mediated signal transduction