Rabbit anti-Human Lad Polyclonal Antibody | anti-Lad antibody

Lad (I249) Polyclonal Antibody

Cat. Num. AAA3013739

• Gene Names: SH2D2A; SCAP; TSAD; VRAP; F2771
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: Lad; Polyclonal Antibody; Lad (I249) Polyclonal Antibody; SCAP; SH2 domain containing adapter protein; SH2 domain containing protein 2A; SH2 domain protein 2A; SH2 domain-containing adapter protein; SH2 domain-containing protein 2A; SH22A; Sh2d2a; T cell specific adapter protein; T cell specific adapter protein TSAd; T cell specific adpater protein TSAd; T cell-specific adapter protein; T lymphocyte specific adaptor protein; TSAd; VEGF receptor associated protein; VEGF receptor-associated protein; VRAP; anti-Lad antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Lad (I249) polyclonal antibody detects endogenous levels of Lad protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 371

• Applicable Applications for anti-Lad antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:500-1:1000; IHC: 1:50-1:200
• Immunogen: Synthetic peptide, corresponding to amino acids 218-260 of Human Lad.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry (IHC) analyzes of Lad (I249) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.)

Related Product Information for anti-Lad antibody

Lad (TSAD, TSAd, F2771, SH2D2A, SH2 domain protein 2A) is a 52 kDa cytoplasmic adapter protein that undergoes tyrosine-phosphorylation and influences T cell activation. Lad (SH2D2A) mRNA is present in peripheral blood leukocytes, thymus and spleen, and accumulates in the cytoplasm during T cell activation. The Lad gene maps to chromosome 1q21 in a region where alterations are characteristic to lymphomas.

NCBI and Uniprot Product Information

• NCBI GI #: 239787758
• NCBI GeneID: 9047
• NCBI Accession #: NP_001154914.1
• NCBI GenBank Nucleotide #: NP_001154914.1
• UniProt Accession #: Q9NP31
• Molecular Weight: ~ 52kDa
• NCBI Official Full Name: SH2 domain-containing protein 2A isoform 3
• NCBI Official Synonym Full Names: SH2 domain containing 2A
• NCBI Official Symbol: SH2D2A
• NCBI Official Synonym Symbols: SCAP; TSAD; VRAP; F2771
• NCBI Protein Information: SH2 domain-containing protein 2A
• UniProt Protein Name: SH2 domain-containing protein 2A
• Protein Family: Ladinin
• UniProt Gene Name: SH2D2A
• UniProt Synonym Gene Names: SCAP; TSAD; VRAP; TSAd
• UniProt Entry Name: SH22A_HUMAN

NCBI Description

This gene encodes an adaptor protein thought to function in T-cell signal transduction. A related protein in mouse is responsible for the activation of lymphocyte-specific protein-tyrosine kinase and functions in downstream signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Uniprot Description

TSAd: an adaptor protein that may facilitate and regulate interaction of KDR with effector proteins important to endothelial cell survival and proliferation. May play a role in the CD4-p56- LCK-dependent signal transduction pathway in T cells. Could also play an important role in normal and pathological angiogenesis.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: cytoplasm; cytosol

Molecular Function: protein binding; SH3/SH2 adaptor activity; SH3 domain binding

Biological Process: cell proliferation; positive regulation of signal transduction; angiogenesis; signal transduction; cell differentiation; vascular endothelial growth factor receptor signaling pathway