Rabbit BCL2L14 Polyclonal Antibody | anti-BCL2L14 antibody

BCL2L14 Polyclonal Antibody

Cat. Num. AAA3011597

• Gene Names: BCL2L14; BCLG
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunofluorescence
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: BCL2L14; Polyclonal Antibody; BCL2L14 Polyclonal Antibody; Apoptosis facilitator Bcl-2-like protein 14; Bcl2-L-14; Apoptosis regulator Bcl-G; BCLG; anti-BCL2L14 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: BCL2L14 polyclonal antibody detects endogenous levels of BCL2L14 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 252

• Applicable Applications for anti-BCL2L14 antibody: Western Blot (WB), Immunofluorescence (IF)
• Application Notes: WB: 1:500-1:2000; IF: 1:50-1:200
• Immunogen: Recombinant full length Human BCL2L14.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of BCL2L14 polyclonal antibody)

Related Product Information for anti-BCL2L14 antibody

Apoptosis is defined as a set of cascades which, when initiated, program the cell to undergo lethal changes such as membrane blebbing, mitochondrial breakdown and DNA fragmentation. Bcl-2 is one of many key regulators of apoptosis that are essential for proper development, tissue homeostasis and protection against foreign pathogens. Bcl-G, also known as BCL2L14 (BCL2-like 14) or BCLG, is a 327 amino acid cytoplasmic protein that belongs to the Bcl-2 family of apoptosis-regulating proteins. Bcl-G is expressed as three alternatively spliced transcripts designated short, medium and long. The short isoform is testis-specific and localizes to cytosolic organelles, while the long isoform is widely expressed and is distributed throughout the cytosol. Overexpression of Bcl-G induces apoptosis in cells, suggesting a possible role for Bcl-G in tumor suppression.

NCBI and Uniprot Product Information

• NCBI GI #: 13540529
• NCBI GeneID: 79370
• NCBI Accession #: NP_110393.1
• NCBI GenBank Nucleotide #: NP_110393.1
• UniProt Accession #: Q9BZR8
• Molecular Weight: ~ 37kDa
• NCBI Official Full Name: apoptosis facilitator Bcl-2-like protein 14 isoform 2
• NCBI Official Synonym Full Names: BCL2 like 14
• NCBI Official Symbol: BCL2L14
• NCBI Official Synonym Symbols: BCLG
• NCBI Protein Information: apoptosis facilitator Bcl-2-like protein 14
• UniProt Protein Name: Apoptosis facilitator Bcl-2-like protein 14
• Protein Family: Apoptosis facilitator Bcl-2-like protein
• UniProt Gene Name: BCL2L14
• UniProt Synonym Gene Names: BCLG; Bcl2-L-14
• UniProt Entry Name: B2L14_HUMAN

NCBI Description

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Overexpression of this gene has been shown to induce apoptosis in cells. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported for this gene. [provided by RefSeq, May 2009]

Uniprot Description

Bcl-G: Plays a role in apoptosis. Belongs to the Bcl-2 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 12p13-p12

Cellular Component: membrane; cytoplasm; endomembrane system; intracellular organelle; cytosol

Molecular Function: protein binding; protein kinase binding

Biological Process: regulation of apoptosis; apoptosis