Western Blot (WB)
(Western Blot (WB) analysis of TMPO polyclonal antibody)
Rabbit TMPO Polyclonal Antibody | anti-TMPO antibody
TMPO Polyclonal Antibody
IHC: 1:50-1:200
IF: 1:50-1:200
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Western Blot (WB)
(Western Blot (WB) analysis of TMPO polyclonal antibody)
Western Blot (WB)
(Western Blot (WB) analysis of TMPO polyclonal antibody)
Immunohistochemistry (IHC)
(Immunohistochemistry (IHC) analysis of TMPO polyclonal antibody in paraffin-embedded Human Breast Cancer tissue.)
Immunohistochemistry (IHC)
(Immunohistochemistry (IHC) analysis of TMPO polyclonal antibody in paraffin-embedded Human Breast Cancer tissue.)
Immunofluorescence (IF)
(Immunofluorescence analysis of U2OS cells, using TMPO polyclonal antibody)
Immunofluorescence (IF)
(Immunofluorescence analysis of U2OS cells, using TMPO polyclonal antibody)
Western Blot (WB)
(Western Blot analysis of extracts from normal (control) and TMPO knockout (KO) 293T cells, using TMPO antibody.)
Western Blot (WB)
(Western Blot analysis of extracts from normal (control) and TMPO knockout (KO) 293T cells, using TMPO antibody.)
NCBI and Uniprot Product Information
NCBI Description
Through alternative splicing, this gene encodes several distinct LEM domain containing protein isoforms. LEM domain proteins include inner nuclear membrane and intranuclear proteins, and are involved in a variety of cellular functions including gene expression, chromatin organization, and replication and cell cycle control. The encoded alpha isoform is broadly diffuse in the nucleus and contains a lamin binding domain, while the beta and gamma isoforms are localized to the nuclear membrane and contain an HDAC3 interaction domain. The distinct isoforms may compete with each other when acting to chaperone other proteins and regulate transcription. [provided by RefSeq, Aug 2019]
Uniprot Description
TMPO: a single-pass type II membrane protein. Tightly associated with the nuclear lamina. Binds DNA and involved in DNA replication and chromatin remodeling, May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with HAP95. Associated with dilated cardiomyopathy; upregulated in medulloblastoma. Used as a pharmaceutical to treat primary and secondary immune deficiencies, autoimmunity, infections and cancer. Available under the names Timunox (Cilag), Sintomodulina (Italofarmaco) and Mepentil (Recordati). Three alternatively spliced isoforms have been described.
Protein type: DNA-binding; Membrane protein, integral
Chromosomal Location of Human Ortholog: 12q22
Cellular Component: nuclear membrane; membrane; cytoplasm; integral to membrane; nuclear inner membrane; nuclear envelope; chromatin; nucleus
Molecular Function: protein binding; DNA binding; lamin binding
Biological Process: regulation of transcription, DNA-dependent
Research Articles on TMPO
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Product Notes
The TMPO tmpo (Catalog #AAA3011024) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TMPO Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TMPO can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). WB: 1:500-1:2000 IHC: 1:50-1:200 IF: 1:50-1:200. Researchers should empirically determine the suitability of the TMPO tmpo for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TMPO, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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