Rabbit anti-Human, Mouse BBS10 Polyclonal Antibody | anti-BBS10 antibody

BBS10 Polyclonal Antibody

Cat. Num. AAA3009789

• Gene Names: BBS10; C12orf58
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: BBS10; Polyclonal Antibody; BBS10 Polyclonal Antibody; C12orf58; anti-BBS10 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: BBS10 polyclonal antibody detects endogenous levels of BBS10 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 723

• Applicable Applications for anti-BBS10 antibody: Western Blot (WB)
• Application Notes: WB: 1:200-1:3000
• Immunogen: Recombinant protein of human BBS10
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot analysis of extracts of various cell lines, using BBS10 antibody at 1:1000 dilution.)

Related Product Information for anti-BBS10 antibody

This gene is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by progressive retinal degeneration, obesity, polydactyly, renal malformation and mental retardation. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene is likely not a ciliary protein but rather has distant sequence homology to type II chaperonins. As a molecular chaperone, this protein may affect the folding or stability of other ciliary or basal body proteins. Inhibition of this protein's expression impairs ciliogenesis in preadipocytes. Mutations in this gene cause Bardet-Biedl syndrome type 10.

NCBI and Uniprot Product Information

• NCBI GI #: 100816407
• NCBI GeneID: 79738
• NCBI Accession #: NP_078961
• NCBI GenBank Nucleotide #: NP_078961.3
• UniProt Accession #: Q8TAM1
• Molecular Weight: 81kDa
• NCBI Official Full Name: Bardet-Biedl syndrome 10 protein
• NCBI Official Synonym Full Names: Bardet-Biedl syndrome 10
• NCBI Official Symbol: BBS10
• NCBI Official Synonym Symbols: C12orf58
• NCBI Protein Information: Bardet-Biedl syndrome 10 protein
• UniProt Protein Name: Bardet-Biedl syndrome 10 protein
• Protein Family: Bardet-Biedl syndrome 10 protein
• UniProt Gene Name: BBS10
• UniProt Synonym Gene Names: C12orf58
• UniProt Entry Name: BBS10_HUMAN

NCBI Description

This gene is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by progressive retinal degeneration, obesity, polydactyly, renal malformation and cognitive disability. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene is likely not a ciliary protein but rather has distant sequence homology to type II chaperonins. As a molecular chaperone, this protein may affect the folding or stability of other ciliary or basal body proteins. Inhibition of this protein's expression impairs ciliogenesis in preadipocytes. Mutations in this gene cause Bardet-Biedl syndrome type 10. [provided by RefSeq, Jan 2010]