Rabbit TNFAIP6 Polyclonal Antibody | anti-TNFAIP6 antibody

TNFAIP6 Polyclonal Antibody

Cat. Num. AAA3007823

• Gene Names: TNFAIP6; TSG6; TSG-6
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: TNFAIP6; Polyclonal Antibody; TNFAIP6 Polyclonal Antibody; Tumor necrosis factor-inducible gene 6 protein; Hyaluronate-binding protein; TNF-stimulated gene 6 protein; TSG-6; Tumor necrosis factor alpha-induced protein 6; TNF alpha-induced protein 6; TSG6; anti-TNFAIP6 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: TNFAIP6 polyclonal antibody detects endogenous levels of TNFAIP6 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 277

• Applicable Applications for anti-TNFAIP6 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:500-1:2000; IHC: 1:50-1:200
• Immunogen: Recombinant full length Human TNFAIP6.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human gastric using TNFAIP6 antibody at dilution of 1:100 (x40 lens).)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded rat kidney using TNFAIP6 antibody at dilution of 1:100 (x40 lens).)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded mouse heart using TNFAIP6 antibody at dilution of 1:100 (x40 lens).)

Western Blot (WB)

(Western Blot analysis of extracts of mouse brain, using TNFAIP6 Antibody.)

Related Product Information for anti-TNFAIP6 antibody

The TSG6 gene is transcribed in normal fibroblasts and activated by binding of the cytokines TNFalpha and IL-1 at AP-1 and NF-IL6 sites in its promoter. TSG-6 is a glycoprotein and a member of the hyaluronan-binding protein family, which includes cartilage link protein, proteoglycan core protein and the adhesion receptor CD44. TSG-6 is highly homologous to CD44, particularly in the hyaluronic acid-binding domain. TSG-6 is found in TNF-treated cells; its expression is rapidly activated by TNFalpha, IL-1 and lipopolysaccharide in normal fibroblasts, peripheral blood mononuclear cells, synovial cells and chondrocytes. The presence of TSG-6 in synovial fluid suggests a possible role in rheumatoid arthritis. TSG-6 forms a stable complex with components of the serine protease inhibitor, inter-alpha-inhibitor (IalphaI)). TSG-6 potentiates the inhibitory effect of lalphal on the protease activity of plasmin. Through their cooperative inhibitory effect on plasmin, TSG-6 and lalphal can modulate the protease network and thus inhibit inflammation.

NCBI and Uniprot Product Information

• NCBI GI #: 26051243
• NCBI GeneID: 7130
• NCBI Accession #: NP_009046.2
• NCBI GenBank Nucleotide #: NP_009046.2
• UniProt Accession #: P98066
• Molecular Weight: ~ 40kDa
• NCBI Official Full Name: tumor necrosis factor-inducible gene 6 protein
• NCBI Official Synonym Full Names: TNF alpha induced protein 6
• NCBI Official Symbol: TNFAIP6
• NCBI Official Synonym Symbols: TSG6; TSG-6
• NCBI Protein Information: tumor necrosis factor-inducible gene 6 protein
• UniProt Protein Name: Tumor necrosis factor-inducible gene 6 protein
• Protein Family: Tumor necrosis factor-inducible gene 6 protein
• UniProt Gene Name: TNFAIP6
• UniProt Synonym Gene Names: TSG6; TSG-6; TNF alpha-induced protein 6

NCBI Description

The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.[provided by RefSeq, Dec 2010]

Uniprot Description

TNFAIP6: Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.

Chromosomal Location of Human Ortholog: 2q23.3

Molecular Function: protein binding

Biological Process: cell-cell signaling; inflammatory response; negative regulation of inflammatory response; signal transduction