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Western Blot (WB) (Western Blot (WB) analysis of CMTM3 polyclonal antibody at 1:500 dilutionLane1:The Testis tissue lysate of Rat (40ug) Lane2:CT26 whole cell lysate (40ug) Lane3:A549 whole cell lysate (40ug) Lane4:COS-7 whole cell lysate (40ug))

Rabbit CMTM3 Polyclonal Antibody | anti-CMTM3 antibody

CMTM3 Polyclonal Antibody

Reactivity
Human, Mouse, Rat
Applications
Western Blot
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Synonyms
CMTM3; Polyclonal Antibody; CMTM3 Polyclonal Antibody; CKLF-like MARVEL transmembrane domain-containing protein 3; Chemokine-like factor superfamily member 3; CKLFSF3; anti-CMTM3 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
CMTM3 polyclonal antibody detects endogenous levels of CMTM3 protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Form/Format
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Sequence Length
182
Applicable Applications for anti-CMTM3 antibody
Western Blot (WB)
Application Notes
WB: 1:500-1:1000
Immunogen
Synthetic peptide, corresponding Human CMTM3.
Preparation and Storage
Store at 4 degree C short term.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of CMTM3 polyclonal antibody at 1:500 dilutionLane1:The Testis tissue lysate of Rat (40ug) Lane2:CT26 whole cell lysate (40ug) Lane3:A549 whole cell lysate (40ug) Lane4:COS-7 whole cell lysate (40ug))

Western Blot (WB) (Western Blot (WB) analysis of CMTM3 polyclonal antibody at 1:500 dilutionLane1:The Testis tissue lysate of Rat (40ug) Lane2:CT26 whole cell lysate (40ug) Lane3:A549 whole cell lysate (40ug) Lane4:COS-7 whole cell lysate (40ug))
Related Product Information for anti-CMTM3 antibody
Chemokines are members of a superfamily of small inducible, secreted, proinflammatory cytokines. Members of the chemokine-like factor superfamily (CKLFSF) share similarities with both chemokine and transmembrane 4 superfamilies of signaling molecules. As a member of the CKLFSF family of proteins, CMTM3 (CKLF-like MARVEL transmembrane domain-containing protein 3), also known as Chemokine-like factor superfamily member 3, is a 182 amino acid membrane protein that is expressed in placenta, testis and leukocytes. The gene encoding CMTM3 resides in a tight gene cluster on human chromosome 16 with CKLF, CMTM1, CMTM2 and CMTM4. Silencing or downregulation of CMTM3 due to aberrant promoter CpG methylation of its gene is frequently observed in common carcinomas, suggesting that CMTM3 is a tumor supressor. CMTM3 also seems to repress activation of AR (androgen receptor) and may therefore play a role in the maturation and maintenance of male reproduction. There are two isoforms of CMTM3 that are produced as a result of alternative splicing events.

NCBI and Uniprot Product Information

NCBI GI #
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
~ 19kDa
NCBI Official Full Name
CKLF-like MARVEL transmembrane domain-containing protein 3
UniProt Protein Name
CKLF-like MARVEL transmembrane domain-containing protein 3
UniProt Gene Name
CMTM3
UniProt Synonym Gene Names
CKLFSF3
UniProt Entry Name
CKLF3_HUMAN

Uniprot Description

CMTM3: a member of the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. Alternatively spliced transcript variants containing different 5' UTRs, but encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Protein type: Cytokine; Membrane protein, integral; Motility/polarity/chemotaxis; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 16q21

Cellular Component: extracellular space; nuclear membrane; cytoplasm; integral to membrane

Molecular Function: cytokine activity

Biological Process: positive regulation of B cell receptor signaling pathway; chemotaxis

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Product Notes

The CMTM3 cmtm3 (Catalog #AAA3007520) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CMTM3 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CMTM3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500-1:1000. Researchers should empirically determine the suitability of the CMTM3 cmtm3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CMTM3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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