Rabbit CCBE1 Polyclonal Antibody | anti-CCBE1 antibody

CCBE1 Polyclonal Antibody

Cat. Num. AAA3006535

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: CCBE1; Polyclonal Antibody; CCBE1 Polyclonal Antibody; Collagen and calcium-binding EGF domain-containing protein 1; Full of fluid protein homolog; KIAA1983; UNQ1921/PRO4395; anti-CCBE1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: CCBE1 polyclonal antibody detects endogenous levels of CCBE1 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 406

• Applicable Applications for anti-CCBE1 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to residues in Human CCBE1.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of CCBE1 polyclonal antibody at 1:500 dilutionLane1:Hela cell lysate Lane2:sp2/0 cell lysateLane3:PC12 cell lysate)

Related Product Information for anti-CCBE1 antibody

The gene encoding CCBE1 (Collagen and calcium-binding EGF domain-containing protein 1) is located on chromosome 18 in a region that is frequently found to be deleted in breast and prostate cancers. CCBE1 is a 406 amino acid secreted protein that contains two collagen-like domains and one calcium-binding epidermal growth factor (EGF-like) domain. In general, EGF-like domains include six cysteine residues that are usually involved in disulfide bonds. Calcium-binding EGF-like domains are subject to amino acid substitutions that disrupt their structure or calcium affinity, therefore altering protein function. Downregulation of the gene encoding CCBE1 is observed with high frequency in breast cancer, suggesting that loss of CCBE1 results in changes in cell adhesion and mobility due to its characterization as an extracellular protein. There are three named isoforms of CCBE1 which are produced as a result of alternative splicing events.

NCBI and Uniprot Product Information

• NCBI GI #: 39930511
• NCBI Accession #: NP_597716.1
• NCBI GenBank Nucleotide #: NP_597716.1
• UniProt Accession #: Q6UXH8
• Molecular Weight: ~ 44kDa
• NCBI Official Full Name: collagen and calcium-binding EGF domain-containing protein 1
• UniProt Protein Name: Collagen and calcium-binding EGF domain-containing protein 1
• Protein Family: Collagen and calcium-binding EGF domain-containing protein
• UniProt Gene Name: CCBE1
• UniProt Synonym Gene Names: KIAA1983

Uniprot Description

Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis.