Rabbit RGS17 Polyclonal Antibody | anti-RGS17 antibody

RGS17 Polyclonal Antibody

Cat. Num. AAA3006473

• Gene Names: RGS17; RGSZ2; RGS-17; hRGS17
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: RGS17; Polyclonal Antibody; RGS17 Polyclonal Antibody; Regulator of G-protein signaling 17; anti-RGS17 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: RGS17 polyclonal antibody detects endogenous levels of RGS17 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 210

• Applicable Applications for anti-RGS17 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to residues in Human RGS17.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of RGS17 polyclonal antibody at 1:500 dilutionLane1:HEK293T whole cell lysateLane2:Raw264. 7 whole cell lysateLane3:H9C2 whole cell lysate)

Related Product Information for anti-RGS17 antibody

The regulators of G protein signaling (RGS) proteins inhibit heterotrimeric G protein signaling. RGS proteins work by functioning as GTPase-activating proteins (which increase the GTPase activity of G protein a-subunits) thereby driving G proteins into their inactive GDP-bound form. The human gene that encodes RGS17 (regulator of G protein signaling 17, RGS17) contains 4 exons, spans more than 33 kb and maps to chromosome 6q25.3; the mouse Rgs17 gene maps to chromosome 10 as determined by interspecific backcross mapping. RGS17 is a member of the RZ/A protein family. RZ/A proteins have a simple structure that consists of a conserved amino-terminal cysteine string motif, RGS box and short carboxyl-terminal, which confer GAP activity and the ability to undergo covalent modification and associate with other proteins (at their amino-termini).

NCBI and Uniprot Product Information

• NCBI GI #: 21361405
• NCBI GeneID: 26575
• NCBI Accession #: NP_036551.3
• NCBI GenBank Nucleotide #: NP_036551.3
• UniProt Accession #: Q9UGC6
• Molecular Weight: ~ 18kDa
• NCBI Official Full Name: regulator of G-protein signaling 17
• NCBI Official Synonym Full Names: regulator of G protein signaling 17
• NCBI Official Symbol: RGS17
• NCBI Official Synonym Symbols: RGSZ2; RGS-17; hRGS17
• NCBI Protein Information: regulator of G-protein signaling 17
• UniProt Protein Name: Regulator of G-protein signaling 17
• Protein Family: Regulator of G-protein signaling
• UniProt Gene Name: RGS17
• UniProt Synonym Gene Names: RGS17
• UniProt Entry Name: RGS17_HUMAN

NCBI Description

This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]

Uniprot Description

RGS17: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G- protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins.

Protein type: GAPs; GAPs, RGS

Chromosomal Location of Human Ortholog: 6q25.3

Cellular Component: cytoplasm; plasma membrane; nucleus

Molecular Function: GTPase activator activity

Biological Process: positive regulation of GTPase activity