Rabbit Ataxin-10 Polyclonal Antibody | anti-Ataxin-10 antibody

Ataxin-10 Polyclonal Antibody

Cat. Num. AAA3006382

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: Ataxin-10; Polyclonal Antibody; Ataxin-10 Polyclonal Antibody; Ataxin 10; Ataxin10; Brain protein E46 homolog; Spinocerebellar ataxia type 10 protein; ATXN10; SCA10; anti-Ataxin-10 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Ataxin-10 polyclonal antibody detects endogenous levels of Ataxin-10 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 475

• Applicable Applications for anti-Ataxin-10 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to residues in Human Ataxin-10.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of Ataxin-10 polyclonal antibody at 1:500 dilutionLane1:Hela whole cell lysateLane2:sp2/0 whole cell lysateLane3:H9C2 whole cell lysate)

Related Product Information for anti-Ataxin-10 antibody

Spinocerebellar ataxia (SCA) is an autosomal dominant neurodegenerative disorder characterized by ataxia and selective neuronal cell loss. SCA is caused by the expansion of a translated CAG repeat, encoding a polyglutamine tract in SCA gene products, known as ataxins. The ataxin proteins are ubiquitously expressed in nervous tissue, but are primarily detected in cerebellum, brain stem and spinal cord in the central nervous system. Ataxin-10 is a cytoplasmic protein that belongs to the family of armadillo repeat proteins. A loss of ataxin-10 in primary neuronal cells causes increased apoptosis of cerebellar neurons. Ataxin-10 interacts with p110, an O-Linked beta-N-acetylglucosamine transferase, and may be important in the regulation of intracellular glycosylation levels and homeostasis in the brain. Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant disorder that causes cerebellar ataxia and seizures. SCA10 is caused by an expansion of an ATTCT pentanucleotide repeat in intron 9 of the ataxin-10 gene.

NCBI and Uniprot Product Information

• NCBI GI #: 17372671
• UniProt Accession #: Q9UBB4
• Molecular Weight: ~ 46-53kDa
• NCBI Official Full Name: Ataxin-10
• UniProt Protein Name: Ataxin-10
• Protein Family: Ataxin
• UniProt Gene Name: ATXN10
• UniProt Synonym Gene Names: SCA10
• UniProt Entry Name: ATX10_HUMAN

Uniprot Description

ataxin-10: Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis. Defects in ATXN10 are the cause of spinocerebellar ataxia type 10 (SCA10). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA10 is an autosomal dominant cerebellar ataxia (ADCA). Defects in ATXN1 may be a cause of nephronophthisis a chronic tubulo-interstitial nephropathy taht leads to anemia, polyuria, polydipsia, isosthenuria and death in uremia. Belongs to the ataxin-10 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation

Chromosomal Location of Human Ortholog: 22q13.31

Cellular Component: extracellular space; cell soma; membrane; perinuclear region of cytoplasm; cytoplasm; dendrite; plasma membrane; cytosol

Molecular Function: identical protein binding; protein binding

Biological Process: nervous system development; neurite development

Disease: Spinocerebellar Ataxia 10