ZADH1 blocking peptide

ZADH1 Peptide

Cat. Num. AAA3006308

• Gene Names: PTGR2; PGR2; ZADH1; HEL-S-298
• Applications: Blocking
• Purity: Synthetic peptide ZADH1. (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: ZADH1; ZADH1 Peptide; Prostaglandin reductase 2; PRG-2; PRG2; 15-oxoprostaglandin 13-reductase; Zinc-binding alcohol dehydrogenase domain-containing protein 1; PTGR2; ZADH1 blocking peptide

• Specificity: This peptide can be used with studies using MBS3006307 ZADH1 pAb.
• Purity/Purification: Synthetic peptide ZADH1. (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 351

• Applicable Applications for ZADH1 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for ZADH1 blocking peptide

ZADH1 (zinc binding alcohol dehydrogenase, domain containing 1), also known as PTGR2 (prostaglandin reductase 2), PGR2 or 15-oxoprostaglandin 13-reductase, is a 351 amino acid cytoplasmic protein that belongs to the NADP-dependent oxidoreductase L4BD family. Functioning as s a 15-oxoprostaglandin 13-reductase, ZADH1 catalyzes the conversion of 15-keto-prostaglandin E2 to 15-keto-13, 14-dihydro-prostaglandin E2 in a NADPH-dependent manner. ZADH1 overexpression has been found to repress PPARgamma transcriptional activity and adipocyte differentiation. Widely expressed, ZADH1 is found at highest levels in heart, kidney, liver, pancreas and prostate, with moderate levels found in brain, small intestine, lung, testis and skeletal muscle. ZADH1 exists as a monomer, utilizes NADPH as a cofactor, and undergoes alternative splicing to produce two isoforms that are encoded by a gene located on human chromosome 14q24.3.

NCBI and Uniprot Product Information

• NCBI GI #: 226246680
• NCBI GeneID: 145482
• NCBI Accession #: NP_001139626.1
• NCBI GenBank Nucleotide #: NP_001139626.1
• UniProt Accession #: Q8N8N7
• NCBI Official Full Name: prostaglandin reductase 2 isoform 1
• NCBI Official Synonym Full Names: prostaglandin reductase 2
• NCBI Official Symbol: PTGR2
• NCBI Official Synonym Symbols: PGR2; ZADH1; HEL-S-298
• NCBI Protein Information: prostaglandin reductase 2
• UniProt Protein Name: Prostaglandin reductase 2
• UniProt Gene Name: PTGR2
• UniProt Synonym Gene Names: ZADH1; PRG-2
• UniProt Entry Name: PTGR2_HUMAN

NCBI Description

This gene encodes an enzyme involved in the metabolism of prostaglandins. The encoded protein catalyzes the NADPH-dependent conversion of 15-keto-prostaglandin E2 to 15-keto-13,14-dihydro-prostaglandin E2. This protein may also be involved in regulating activation of the peroxisome proliferator-activated receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

Uniprot Description

PTGR2: Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto- PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation. Belongs to the NADP-dependent oxidoreductase L4BD family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.3.1.48; Oxidoreductase

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: cytoplasm

Molecular Function: 15-oxoprostaglandin 13-oxidase activity; zinc ion binding

Biological Process: prostaglandin metabolic process