Septin 6 Blocking Peptide | SEPTIN6 blocking peptide

Septin 6 Peptide

Cat. Num. AAA3006204

• Gene Names: SEPTIN6; SEP2; SEPT2; SEPT6
• Applications: Blocking
• Purity: Synthetic peptide Septin 6. (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: Septin 6; Septin 6 Peptide; Septin6; Septin-6; SEPT6; KIAA0128; SEP2; SEPTIN6 blocking peptide

• Specificity: This peptide can be used with studies using MBS3006203 Septin 6 pAb.
• Purity/Purification: Synthetic peptide Septin 6. (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 434

• Applicable Applications for SEPTIN6 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for SEPTIN6 blocking peptide

Septin 6, also known as SEPT6, is a 434 amino acid protein that belongs to the septin family. The highly conserved septin family of GTP-binding cytoskeletal proteins is implicated in membrane transport, apoptosis, cell polarity, cell cycle regulation, cytokinesis and other cellular functions. Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. Filaments are assembled from asymmetrical heterotrimers, composed of Septin 2, Septin 6 and Septin 7 that associate head-to-head to form a hexameric unit, however interaction with Septin 12 alters filament structure. Septin 6 shares 40% identity with CDC10 and contains an ATP/GTP-binding site motif. The Septin 6 protein demonstrates nearly ubiquitous expression, with highest level in thymus. The Septin 6 protein is phosphorylated upon DNA damage, probably by Atm or ATR.

NCBI and Uniprot Product Information

• NCBI GI #: 21361478
• NCBI GeneID: 23157
• NCBI Accession #: NP_055944.2
• NCBI GenBank Nucleotide #: NP_055944.2
• UniProt Accession #: Q14141
• NCBI Official Full Name: septin-6 isoform B
• NCBI Official Synonym Full Names: septin 6
• NCBI Official Symbol: SEPTIN6
• NCBI Official Synonym Symbols: SEP2; SEPT2; SEPT6
• NCBI Protein Information: septin-6
• UniProt Protein Name: Septin-6
• UniProt Gene Name: SEPT6
• UniProt Synonym Gene Names: KIAA0128; SEP2
• UniProt Entry Name: SEPT6_HUMAN

NCBI Description

This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

SEPT6: Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Belongs to the septin family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Hydrolase; Cytoskeletal

Chromosomal Location of Human Ortholog: Xq24

Cellular Component: synaptic vesicle; spindle; midbody; nerve terminal; cleavage furrow

Molecular Function: protein binding; GTP binding

Biological Process: viral reproduction; cytokinesis