Rabbit GPR105 Polyclonal Antibody | anti-GPR105 antibody

GPR105 Polyclonal Antibody

Cat. Num. AAA3005882

• Gene Names: P2RY14; P2Y14; BPR105; GPR105
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunocytochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: GPR105; Polyclonal Antibody; GPR105 Polyclonal Antibody; P2Y purinoceptor 14; P2Y14; G-protein coupled receptor 105; UDP-glucose receptor; P2RY14; KIAA000; anti-GPR105 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: GPR105 polyclonal antibody detects endogenous levels of GPR105 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 338

• Applicable Applications for anti-GPR105 antibody: Western Blot (WB), Immunocytochemistry (ICC)
• Application Notes: WB: 1:500-1:1000; ICC: 1:50-1:200
• Immunogen: Synthetic peptide, corresponding to amino acids 197-242 of Human GPR105.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of GPR105 polyclonal antibody at 1:500 dilutionLane1:HEK293T cell lysateLane2:Raw264. 7 cell lysateLane3:Rat kidney tissue lysate)

Related Product Information for anti-GPR105 antibody

G protein-coupled receptors (GPRs) are a protein family of transmembrane receptors that transmit an extracellular signal (ligand binding) into an intracellular signal (G protein activation). GPR signaling is an evolutionarily ancient mechanism used by all eukaryotes to sense environmental stimuli and mediate cell-cell communication. All of the receptors have seven membrane-spanning domains and the extracellular parts of the receptor can be glycosylated. These extracellular loops also contain two highly conserved cysteine residues which create disulfide bonds to stabilize the receptor structure. GPR105, also designated P2Y14, is widely expressed throughout many brain regions where it localizes to glial cells, and specifically co-localizes with astrocytes. GPR105 is upregulated when a tissue is immunologically challenged with lipopolysaccharide, leading to the theory that GPR105 may play an important role in modulating peripheral and neuroimmune function.

NCBI and Uniprot Product Information

• NCBI GI #: 125625354
• NCBI GeneID: 9934
• NCBI Accession #: NP_001074924.1
• NCBI GenBank Nucleotide #: NP_001074924.1
• UniProt Accession #: Q15391
• Molecular Weight: ~ 39kDa
• NCBI Official Full Name: P2Y purinoceptor 14
• NCBI Official Synonym Full Names: purinergic receptor P2Y14
• NCBI Official Symbol: P2RY14
• NCBI Official Synonym Symbols: P2Y14; BPR105; GPR105
• NCBI Protein Information: P2Y purinoceptor 14
• UniProt Protein Name: P2Y purinoceptor 14
• UniProt Gene Name: P2RY14
• UniProt Synonym Gene Names: GPR105; KIAA0001; P2Y14
• UniProt Entry Name: P2Y14_HUMAN

NCBI Description

The product of this gene belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

P2RY14: Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 3q24-q25.1

Cellular Component: integral to plasma membrane; integral to membrane; plasma membrane

Molecular Function: UDP-activated nucleotide receptor activity; purinergic nucleotide receptor activity, G-protein coupled

Biological Process: G-protein coupled receptor protein signaling pathway