AOX1 blocking peptide

AOX1 Peptide

Cat. Num. AAA3005678

• Applications: Blocking
• Purity: Synthetic peptide AOX1. (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: AOX1; AOX1 Peptide; Aldehyde oxidase; Aldehyde oxidase 1; Azaheterocycle hydroxylase; AO; AOX-1; AOX1 blocking peptide

• Specificity: This peptide can be used with studies using MBS3005677 AOX1 pAb.
• Purity/Purification: Synthetic peptide AOX1. (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 1338

• Applicable Applications for AOX1 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for AOX1 blocking peptide

AOX1 (Aldehyde oxidase 1) is a 1338 amino acid cytoplasmic protein that catalyzes the oxidation of a variety of aldehydes, leading to the production of hydrogen peroxide. Under certain conditions, AOX1 can catalyze the formation of the superoxide free radical. Defects in oxygen radical metabolism have been linked to the pathogenesis of amyotrophic lateral sclerosis (ALS), an autosomal dominant neurodegenerative disorder characterized by the death of motor neurons in the spinal cord, brain and brainstem. Significantly, AOX1 is highly expressed in the ventral horn of the spinal cord and the gene that encodes AOX1 is located in a chromosomal region that is frequently found to be implicated in ALS2. This evidence suggests that AOX1 is a candidate gene for ALS2.

NCBI and Uniprot Product Information

• NCBI GI #: 71773480
• NCBI Accession #: NP_001150.3
• NCBI GenBank Nucleotide #: NP_001150.3
• UniProt Accession #: Q06278
• NCBI Official Full Name: aldehyde oxidase
• UniProt Protein Name: Aldehyde oxidase
• Protein Family: Alcohol oxidase
• UniProt Gene Name: AOX1
• UniProt Synonym Gene Names: AO
• UniProt Entry Name: ADO_HUMAN

Uniprot Description

AOX1: Aldehyde oxidase produces hydrogen peroxide and, under certain conditions, can catalyze the formation of superoxide. Aldehyde oxidase is a candidate gene for amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2008]

Protein type: EC 1.2.3.1; Oxidoreductase; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Amino Acid Metabolism - tyrosine; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Cofactor and Vitamin Metabolism - vitamin B6

Chromosomal Location of Human Ortholog: 2q33

Cellular Component: cytoplasm; cytosol

Molecular Function: molybdopterin cofactor binding; 2 iron, 2 sulfur cluster binding; UDP-N-acetylmuramate dehydrogenase activity; FAD binding; electron carrier activity; iron ion binding; aldehyde oxidase activity; xanthine dehydrogenase activity; NAD binding

Biological Process: vitamin metabolic process; vitamin B6 metabolic process; inflammatory response; water-soluble vitamin metabolic process