Rabbit SLC16A13 Polyclonal Antibody | anti-SLC16A13 antibody

SLC16A13 (L423) Polyclonal Antibody

Cat. Num. AAA3003464

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: SLC16A13; Polyclonal Antibody; SLC16A13 (L423) Polyclonal Antibody; Monocarboxylate transporter 13; MCT 13; Solute carrier family 16 member 13; MCT13; anti-SLC16A13 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: SLC16A13 (L423) polyclonal antibody detects endogenous levels of SLC16A13 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 426

• Applicable Applications for anti-SLC16A13 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: Synthetic peptide, corresponding to amino acids 389-442 of Human SLC16A13.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of SLC16A13 (L423) pAb at 1:500 dilutionLane1:C6 whole cell lysate (40ug) Lane2:3T3-L1 whole cell lysate (40ug) Lane3:MCF-7 whole cell lysate (40ug) Lane4:HepG2 whole cell lysate (40ug) Lane5:H1792 whole cell lysate (20ug))

Related Product Information for anti-SLC16A13 antibody

Monocarboxylates, such as lactate and pyruvate, play an integral role in cellular metabolism. Lactic acid is produced in large quantities as a result of glycolysis, which provides the majority of ATP to cells under normal physiological conditions. However, accumulation of lactic acid leads to a decrease in intracellular pH and, thus, to a cessation of glycolysis. In order for glycolysis to continue at a high rate, lactic acid must be transported out of the cell. This transport process is carried out by a family of monocarboxylate transporters (MCTs), which function as proton symports and are stereoselective for L-lactate. MCT13 (Monocarboxylate transporter 13), also known as SLC16A13 (Solute carrier family 16 member 13), is a 426 amino acid multi-pass membrane protein that belongs to the MCT transport family. Functioning as a proton-linked monocarboxylate transporter, MCT13 catalyzes the rapid transports of molecules, such as lactate, across the plasma membrane.

NCBI and Uniprot Product Information

• NCBI GI #: 42475555
• NCBI Accession #: NP_963860.1
• NCBI GenBank Nucleotide #: NP_963860.1
• UniProt Accession #: Q7RTY0
• Molecular Weight: ~ 40kDa
• NCBI Official Full Name: monocarboxylate transporter 13
• UniProt Protein Name: Monocarboxylate transporter 13
• Protein Family: Monocarboxylate transporter
• UniProt Gene Name: SLC16A13
• UniProt Synonym Gene Names: MCT13; MCT 13
• UniProt Entry Name: MOT13_HUMAN

Uniprot Description

SLC16A13: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates. Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: Golgi membrane; Golgi apparatus; integral to membrane

Molecular Function: monocarboxylic acid transmembrane transporter activity; symporter activity

Biological Process: monocarboxylic acid transport