Per3 blocking peptide

Per3 (P2) Peptide

Cat. Num. AAA3002418

• Gene Names: PER3; GIG13; FASPS3
• Applications: Blocking
• Purity: Synthetic peptide Per3 (P2). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: Per3; Per3 (P2) Peptide; PER3; GIG13; HPER3; Per3 blocking peptide

• Specificity: This peptide can be used with studies using MBS3002417 Per3 (P2) pAb.
• Purity/Purification: Synthetic peptide Per3 (P2). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 1201

• Applicable Applications for Per3 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for Per3 blocking peptide

Biological timepieces called circadian clocks are responsible for the regulation of hormonal rhythms, sleep cycles and other behaviors. The superchiasmatic nucleus (SCN), which is located in the brain, was the first mammalian circadian clock to be discovered. A number of transcription factors appearing to be molecular components of the SCN clock have been identified. Mutations within the Clock gene increase the length of the endogenous period and cause a loss of rhythmicity of circadian oscillations. Three mammalian period proteins, designated Per1, Per2 and Per3, exhibit circadian rhythyms in the SCN.During subjective night, Per1 and Per2 RNA levels increase in response to light pulses while Per3 RNA levels show no change in response to light pulses. Tim, for timeless, interacts with Per1 as well as Per2; and Tim and Per1 negatively regulate Clock-BMAL1-induced transcription.

NCBI and Uniprot Product Information

• NCBI GI #: 317373535
• NCBI GeneID: 8863
• UniProt Accession #: P56645; Q8TAR6
• NCBI Official Full Name: Period circadian protein homolog 3
• NCBI Official Synonym Full Names: period circadian regulator 3
• NCBI Official Symbol: PER3
• NCBI Official Synonym Symbols: GIG13; FASPS3
• NCBI Protein Information: period circadian protein homolog 3
• UniProt Protein Name: Period circadian protein homolog 3
• Protein Family: Period circadian protein
• UniProt Gene Name: PER3
• UniProt Synonym Gene Names: hPER3
• UniProt Entry Name: PER3_HUMAN

NCBI Description

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been linked to sleep disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2014]

Uniprot Description

PER3: Component of the circadian clock mechanism which is essential for generating circadian rhythms. Can bind heme. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 1p36.23

Cellular Component: cytoplasm; nucleus

Molecular Function: signal transducer activity; protein binding; ubiquitin protein ligase binding; kinase binding

Biological Process: transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; circadian regulation of gene expression; signal transduction; regulation of circadian sleep/wake cycle, sleep