AKAP 5 Blocking Peptide | AKAP5 blocking peptide

AKAP 5 (E7) Peptide

Cat. Num. AAA3001951

• Gene Names: AKAP5; H21; AKAP75; AKAP79
• Applications: Blocking
• Purity: Synthetic peptide AKAP 5 (E7). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: AKAP 5; AKAP 5 (E7) Peptide; A kinase (PRKA) anchor protein 5; A kinase anchor protein 5; A kinase anchor protein 79kDa; A-kinase anchor protein 5; A-kinase anchor protein 79 kDa; AKAP 79; AKAP-5; AKAP5; AKAP75; AKAP79; AKAP5 blocking peptide

• Specificity: This peptide can be used with studies using MBS3001950 AKAP 5 (E7) pAb.
• Purity/Purification: Synthetic peptide AKAP 5 (E7). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 427

• Applicable Applications for AKAP5 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for AKAP5 blocking peptide

AKAPs (A-kinase anchoring proteins), as their name implies, are a family of scaffolding proteins that bind regulatory subunits of Protein Kinase A (PKA) thus localizing PKA activity to distinct regions of the cell. Beyond a common amphipathic alpha helix that is responsible for recruiting the PKA regulatory subunit (RIalpha, RIIalpha, RIbeta, or RIIbeta), individual AKAPs contain additional domains responsible for the recrutiment of additional signaling proteins (phosphodiesterases, phosphatases, cytoskeletal components, other kinase, etc.) or restricting AKAP to a specific subcellular location. AKAP5 (also known as P75, AKAP75, or AKAP79) is predominantly expressed in neuronal tissues and cells where it serves to localize type II PKA to post-synaptic densities. AKAP5 specifically binds to the regulatory subunit of PKAIIbeta, anchoring the enzyme to the plasma membrane and sites of cytoskeletal/membrane junctions. The other binding domains of AKAP5 have been shown to interact with calmodulin, PP2B, and calcineurin suggesting that AKAP5 may act to coordinate the cAMP- and Ca2+-sensing pathways in various cell types.

NCBI and Uniprot Product Information

• NCBI GI #: 158187521
• NCBI GeneID: 9495
• NCBI Accession #: NP_004848.3
• NCBI GenBank Nucleotide #: NP_004848.3
• UniProt Accession #: P24588
• NCBI Official Full Name: A-kinase anchor protein 5
• NCBI Official Synonym Full Names: A-kinase anchoring protein 5
• NCBI Official Symbol: AKAP5
• NCBI Official Synonym Symbols: H21; AKAP75; AKAP79
• NCBI Protein Information: A-kinase anchor protein 5
• UniProt Protein Name: A-kinase anchor protein 5
• Protein Family: A-kinase anchor protein
• UniProt Gene Name: AKAP5
• UniProt Synonym Gene Names: AKAP79; AKAP-5; AKAP 79
• UniProt Entry Name: AKAP5_HUMAN

NCBI Description

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT. [provided by RefSeq, Jul 2008]

Uniprot Description

AKAP5: May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Binding protein for dimer of the RII-beta regulatory subunit of cAMP-dependent protein kinase (PKA) and also for the protein kinase C (PKC) and the phosphatase calcineurin (PP2B). Each enzyme is inhibited when bound to the anchoring protein. Also binds the beta2-adrenergic receptor. Part of a complex containing AKAP5, ADCY5, ADCY6 AND PDE4C. Interacts with ADCY8, and enhances its phosphorylation at lipid rafts. Predominantly in the cerebral cortex and the postsynaptic densities of the forebrain, and to a lesser extent in adrenal medulla, lung and anterior pituitary.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 14q23.3

Cellular Component: plasma membrane; cytosol

Molecular Function: calmodulin binding; protein binding; protein kinase A binding; adenylate cyclase binding

Biological Process: synaptic transmission; positive regulation of cAMP biosynthetic process; energy reserve metabolic process; signal transduction; regulation of insulin secretion; protein targeting