Cyclin G Blocking Peptide | I194 blocking peptide

Cyclin G (I194)Peptide

Cat. Num. AAA3000452

• Gene Names: CCNG1; CCNG
• Applications: Blocking
• Purity: Synthetic peptide Cyclin G (I194). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: Cyclin G; Cyclin G (I194)Peptide; Cyclin-G1; Cyclin-G; CCNG1; CCNG; CYCG1; I194 blocking peptide

• Specificity: This peptide can be used with studies using MBS3000451 Cyclin G (I194)pAb.
• Purity/Purification: Synthetic peptide Cyclin G (I194). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 295

• Applicable Applications for I194 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for I194 blocking peptide

Cyclins are the regulatory subunits of Cdc2 p34 and related cyclin-dependent kinases (Cdks) which play critical roles in the control of cell cycle progression. The catalytic subunit for cyclin A and B is Cdc2 p34 kinase. The Cdc2- cyclin B complex controls the G2 to M transition whereas Cdc2-cyclin A regulates S phase progression. The G1 to S transition, however, appears to be controlled by the G1 cyclins. Cyclin D1 accumulates during G1 and associates with Cdk2, Cdk4 and Cdk5. Cyclin E and Cdk2 interact during the G1 to S transition. Cyclin G contains a typical N terminal cyclin box and a carboxy terminal domain sequence homologous to the tyrosine phosphorylation site of the epidermal growth factor receptor. Cyclin G expression is induced within 3 hours after growth stimulation and remains elevated with no apparent cell cycle dependency. Cyclin G2 shares 53% amino acid sequence identity with cyclin G1. Peak expression of cyclin G2 is seen in late S phase, as opposed to cyclin G1 expression, which is constitutive.

NCBI and Uniprot Product Information

• NCBI GI #: 4757934
• NCBI GeneID: 900
• NCBI Accession #: NP_004051.1
• NCBI GenBank Nucleotide #: NP_004051.1
• UniProt Accession #: P51959
• NCBI Official Full Name: cyclin-G1 isoform a
• NCBI Official Synonym Full Names: cyclin G1
• NCBI Official Symbol: CCNG1
• NCBI Official Synonym Symbols: CCNG
• NCBI Protein Information: cyclin-G1
• UniProt Protein Name: Cyclin-G1
• Protein Family: Cyclin
• UniProt Gene Name: CCNG1
• UniProt Synonym Gene Names: CCNG; CYCG1; Cyclin-G
• UniProt Entry Name: CCNG1_HUMAN

NCBI Description

The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

CCNG1: May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation. Belongs to the cyclin family. Cyclin G subfamily.

Protein type: Cell cycle regulation

Chromosomal Location of Human Ortholog: 5q32-q34

Cellular Component: cell soma; perinuclear region of cytoplasm; dendrite; nucleus

Molecular Function: protein domain specific binding; protein binding

Biological Process: mitosis; cell division; mitotic cell cycle G2/M transition DNA damage checkpoint; regulation of cyclin-dependent protein kinase activity; brain development; response to organic nitrogen; cell growth; syncytium formation; negative regulation of apoptosis