Rabbit CaMK1 Polyclonal Antibody | anti-CaMK1 antibody

CaMK1 Rabbit pAb

Cat. Num. AAA4755722

• Gene Names: CAMK1; CAMKI
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry, Immunocytochemistry, Immunofluorescence
• Purity: Affinity Chromatography
• Synonyms: CaMK1; Polyclonal Antibody; CaMK1 Rabbit pAb; CaM K1; CaM KI; CaMK 1; CAMK I; CaMK1 alpha; CAMK1 PEN; CaMKI alpha; anti-CaMK1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Widely expressed. Expressed in cells of the zona glomerulosa of the adrenal cortex.; CaMKI Antibody detects endogenous levels of total CaMKI
• Purity/Purification: Affinity Chromatography
• Form/Format: Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Applicable Applications for anti-CaMK1 antibody: Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P), Immunocytochemistry (ICC), Immunofluorescence (IF)
• Application Notes: WB: 1:500-1:2000; IHC: 1:50-1:200; ICC/IF: 1:50-1:200
• Immunogen: A synthesized peptide derived from human CaMKI
• Conjugation: Unconjugated
• Modification: Unmodified
• Cell Position: Cytoplasm, Nucleus
• Preparation and Storage: Store at 4 degree C for short term. Store at -20 degree C for long term. Avoid freeze/thaw cycle.

Western Blot (WB)

(Western blot analysis of CaMKI expression in SH-SY5Y cell lysate.)

Related Product Information for anti-CaMK1 antibody

Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF].

Product Categories/Family for anti-CaMK1 antibody

Primary antibody

NCBI and Uniprot Product Information

• NCBI GI #: 4502553
• NCBI GeneID: 8536
• NCBI Accession #: NP_003647.1
• NCBI GenBank Nucleotide #: NM_003656.4
• UniProt Accession #: Q14012; Q3KPF6
• Molecular Weight: 41,337 Da
• NCBI Official Full Name: calcium/calmodulin-dependent protein kinase type 1
• NCBI Official Synonym Full Names: calcium/calmodulin-dependent protein kinase I
• NCBI Official Symbol: CAMK1
• NCBI Official Synonym Symbols: CAMKI
• NCBI Protein Information: calcium/calmodulin-dependent protein kinase type 1; caM-KI; caMKI-alpha; caM kinase I alpha
• UniProt Protein Name: Calcium/calmodulin-dependent protein kinase type 1
• Protein Family: Calcium/calmodulin-dependent serine/threonine-protein kinase
• UniProt Gene Name: CAMK1
• UniProt Synonym Gene Names: CaM-KI; CaMKI-alpha
• UniProt Entry Name: KCC1A_HUMAN

NCBI Description

Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase. [provided by RefSeq, Jul 2008]

Uniprot Description

CAMK1A: an ubiquitous protein kinase of the CAMK1 family. Activated by Ca(2+)/calmodulin. Must be phosphorylated to be maximally active. Substrates include synapsin I.

Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; EC 2.7.11.17; CAMK group; CAMK1 family

Chromosomal Location of Human Ortholog: 3p25.3

Cellular Component: cytoplasm; nucleus

Molecular Function: calmodulin binding; protein binding; calmodulin-dependent protein kinase activity; ATP binding

Biological Process: positive regulation of syncytium formation by plasma membrane fusion; regulation of muscle cell differentiation; nucleocytoplasmic transport; signal transduction; cell cycle; protein amino acid phosphorylation; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein export from nucleus; positive regulation of synapse structural plasticity; regulation of protein localization; regulation of protein binding; positive regulation of muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of protein binding