ITGA2B / Integrin Alpha-IIb Recombinant Protein | ITGA2B recombinant protein

Human ITGA2B / Integrin Alpha-IIb Recombinant Protein

• Gene Names: ITGA2B; GT; GTA; CD41; GP2B; HPA3; CD41B; GPIIb; BDPLT2; BDPLT16; PPP1R93
• Applications: ELISA, Western Blot
• Purity: >95% by SDS-PAGE
• Synonyms: ITGA2B / Integrin Alpha-IIb; Human ITGA2B / Integrin Alpha-IIb Recombinant Protein; Integrin alpha-IIb; GPalpha IIb; GPIIb; Platelet membrane glycoprotein IIb; CD41; GP2B; ITGAB; ITGA2B recombinant protein

• Host: E Coli
• Purity/Purification: >95% by SDS-PAGE
• Form/Format: Liquid; 50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10% Glycerol (PH8.0)
• Concentration: Reconstitution Dependent (varies by lot)
• Sequence Length: 1039

• Applicable Applications for ITGA2B recombinant protein: ELISA (EIA), Western Blot (WB), Antigen Protein (AP), Protein Array
• Species: Human
• Tag: His
• Subunit: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3. Directly interacts with RNF181. Interacts (via C-terminus cytoplasmic tail region) with CIB1; the interaction is direct and calcium-dependent. Interacts (via C-terminus cytoplasmic tail region) with CIB2, CIB3 and CIB4; the interactions are stabilized/increased in a calcium and magnesium-dependent manner.
• Entry Function: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
• Preparation and Storage: Store at -20 degree C. Avoid repeated freezing and thawing.

NCBI and Uniprot Product Information

• NCBI GI #: 88758615
• NCBI GeneID: 3674
• NCBI Accession #: NP_000410.2
• NCBI GenBank Nucleotide #: NP_000410.2
• UniProt Accession #: P08514
• NCBI Official Full Name: integrin alpha-IIb preproprotein
• NCBI Official Synonym Full Names: integrin subunit alpha 2b
• NCBI Official Symbol: ITGA2B
• NCBI Official Synonym Symbols: GT; GTA; CD41; GP2B; HPA3; CD41B; GPIIb; BDPLT2; BDPLT16; PPP1R93
• NCBI Protein Information: integrin alpha-IIb
• UniProt Protein Name: Integrin alpha-IIb
• Protein Family: Integrin
• UniProt Gene Name: ITGA2B
• UniProt Synonym Gene Names: GP2B; ITGAB; GPIIb
• UniProt Entry Name: ITA2B_HUMAN

NCBI Description

This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia. [provided by RefSeq, Jan 2016]