Activity-regulated cytoskeleton-associated Protein | ARC protein

Activity-regulated cytoskeleton-associated protein

• Gene Names: ARC; hArc; Arg3.1
• Applications: ELISA, Western Blot
• Purity: >95% by SDS-PAGE
• Synonyms: Activity-regulated cytoskeleton-associated; Activity-regulated cytoskeleton-associated protein; KIAA0278; ARC/ARG3.1; Activity-regulated gene 3.1 protein homolog; Arg3.1; ARC protein

• Host: E Coli
• Purity/Purification: >95% by SDS-PAGE
• Form/Format: Liquid
• Sequence Length: 396

• Applicable Applications for ARC protein: ELISA (EIA), Western Blot (WB), Affinity Purification (AP), Protein Array
• Tags: His
• Storage Buffer: 50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
• Preparation and Storage: Store at -20 degree C.; Avoid repeated freezing and thawing.

NCBI and Uniprot Product Information

• NCBI GI #: 8567330
• NCBI GeneID: 23237
• NCBI Accession #: NP_056008.1
• NCBI GenBank Nucleotide #: NM_015193.4
• UniProt Accession #: Q7LC44; Q9UJW6; Q9Y469
• Molecular Weight: 45,316 Da
• NCBI Official Full Name: activity-regulated cytoskeleton-associated protein
• NCBI Official Synonym Full Names: activity regulated cytoskeleton associated protein
• NCBI Official Symbol: ARC
• NCBI Official Synonym Symbols: hArc; Arg3.1
• NCBI Protein Information: activity-regulated cytoskeleton-associated protein
• UniProt Protein Name: Activity-regulated cytoskeleton-associated protein
• Protein Family: AAA ATPase forming ring-shaped complexes
• UniProt Gene Name: ARC
• UniProt Synonym Gene Names: Arg3.1

Uniprot Description

Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation. ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons. Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory. Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis. Acts as a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum by mediating elimination of surplus climbing fiber synapses. Accumulates at weaker synapses, probably to prevent their undesired enhancement. This suggests that ARC-containing virion-like capsids may be required to eliminate synaptic material. Required to transduce experience into long-lasting changes in visual cortex plasticity and for long-term memory (). Involved in postsynaptic trafficking and processing of amyloid-beta A4 (APP) via interaction with PSEN1 (). In addition to its role in synapses, also involved in the regulation of the immune system: specifically expressed in skin-migratory dendritic cells and regulates fast dendritic cell migration, thereby regulating T-cell activation ().