Rat Copper-transporting ATPase 1 ELISA Kit | Atp7a elisa kit

Rat Copper-transporting ATPase 1 ELISA Kit

Cat. Num. AAA2887110

• Gene Names: Atp7a; Mnk
• Reactivity: Rat
• Synonyms: Copper-transporting ATPase 1; Rat Copper-transporting ATPase 1 ELISA Kit; Copper pump 1; Menkes disease-associated protein homolog; Atp7a; Mnk; 3.6.3.54; Atp7a elisa kit

• Reactivity: Rat
• Sequence Length: 1492

• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 16258817
• NCBI GeneID: 24941
• NCBI Accession #: NP_434690.1
• NCBI GenBank Nucleotide #: NM_052803.2
• UniProt Accession #: P70705
• Molecular Weight: 162,093 Da
• NCBI Official Full Name: copper-transporting ATPase 1
• NCBI Official Synonym Full Names: ATPase copper transporting alpha
• NCBI Official Symbol: Atp7a
• NCBI Official Synonym Symbols: Mnk
• NCBI Protein Information: copper-transporting ATPase 1
• UniProt Protein Name: Copper-transporting ATPase 1
• Protein Family: Copper-transporting ATPase
• UniProt Gene Name: Atp7a
• UniProt Synonym Gene Names: Mnk
• UniProt Entry Name: ATP7A_RAT

NCBI Description

This gene encodes a transmembrane protein that functions in copper transport across membranes. The protein localizes to the trans-Golgi network, where it is predicted to supply copper to copper-dependent enzymes in the secretory pathway. The protein relocalizes to the plasma membrane under conditions of elevated extracellular copper and functions in the efflux of copper from cells. In human, mutations in this gene result in Menkes disease, X-linked cutis laxa, and occipital horn syndrome. [provided by RefSeq, Nov 2009]

Uniprot Description

ATP7A: a multi-pass membrane protein and cation transporting ATPase. A copper-transporter that may supply copper to copper-requiring proteins within the secretory pathway when localized in the trans-Golgi network. Cycles between the trans-Golgi network (TGN) and the plasma membrane. Predominantly found in the TGN and relocalizes to the plasma membrane in response to elevated extracellular copper levels where it functions in the efflux of copper from cells. Defects in ATP7A are the cause of Menkes syndrome (MD) and occipital horn syndrome (OHS). Six alternatively spliced isoforms have been described. The longest isoform has 6 transmembrane regions. Isoform 3, lacking all 6 transmembrane regions and 5 heavy-metal-associated (HMA) domains, is probably cytosolic. Isoform 6 lacks all transmembrane regions and 5 heavy-metal-associated (HMA) domains, but has a putative nuclear localization signal attached at the N-terminus.

Protein type: Vesicle; Chaperone; EC 3.6.3.54; Apoptosis; Membrane protein, multi-pass; Transporter, ion channel; Transporter; Hydrolase; Membrane protein, integral; Cell development/differentiation

Cellular Component: basolateral plasma membrane; brush border membrane; cell soma; cytoplasmic vesicle; endoplasmic reticulum; Golgi apparatus; integral to membrane; integral to plasma membrane; late endosome; membrane; neuron projection; perinuclear region of cytoplasm; plasma membrane; secretory granule; trans-Golgi network; trans-Golgi network transport vesicle

Molecular Function: ATP binding; copper ion binding; copper ion transmembrane transporter activity; copper-dependent protein binding; copper-exporting ATPase activity; metal ion binding; superoxide dismutase copper chaperone activity

Biological Process: alveolus development; ATP metabolic process; blood vessel development; blood vessel remodeling; cartilage development; catecholamine metabolic process; cellular copper ion homeostasis; central nervous system neuron development; cerebellar Purkinje cell differentiation; collagen fibril organization; copper ion export; copper ion import; copper ion transport; dendrite morphogenesis; detoxification of copper ion; dopamine metabolic process; elastic fiber assembly; elastin biosynthetic process; epinephrine metabolic process; extracellular matrix organization and biogenesis; hair follicle morphogenesis; hindlimb morphogenesis; in utero embryonic development; lactation; locomotory behavior; metal ion transport; mitochondrion organization and biogenesis; negative regulation of metalloenzyme activity; negative regulation of neuron apoptosis; neurite morphogenesis; norepinephrine biosynthetic process; norepinephrine metabolic process; peptidyl-lysine modification; pigmentation; plasma membrane copper ion transport; positive regulation of catalytic activity; positive regulation of metalloenzyme activity; positive regulation of oxidoreductase activity; pyramidal neuron development; regulation of gene expression; regulation of oxidative phosphorylation; release of cytochrome c from mitochondria; removal of superoxide radicals; response to copper ion; response to iron(III) ion; response to zinc ion; serotonin metabolic process; skin development; T-helper cell differentiation; tryptophan metabolic process; tyrosine metabolic process